Mirtazapine-Induced Akathisia

Gülsün, Murat; Doruk, Ali

doi:10.1097/jcp.0b013e31817ed22c

Cited by 22 publications

(20 citation statements)

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“… 8 While mirtazapine and mianserin are therapeutic agents for akathisia, they may cause akathisia on their own, and care must be taken when treating patients with akathisia using such medications. 32 , 33 In some cases, anticholinergic drugs cannot be used for treatment of akathisia due to side effects such as ileus, urinary disorders, and elevated intraocular pressure. In addition, anticholinergic drugs lead to tardive dyskinesia after long-term administration.…”

Section: Discussionmentioning

confidence: 99%

Gabapentin enacarbil for antipsychotic induced akathisia in schizophrenia patients: a pilot open-labeled study

Takeshima¹,

Ishikawa

Kanbayashi³

et al. 2018

NDT

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ObjectiveGabapentin and its prodrug are candidate therapeutic agents for akathisia. An open-label pilot study was conducted to investigate the therapeutic potential of gabapentin enacarbil (GE) for akathisia.MethodsIn an open-labeled investigator-initiated clinical trial, nine outpatients with antipsychotics-induced akathisia were administered GE (300 or 600 mg/day) over 2 weeks. The BARS global akathisia score was used to assess akathisia. The BPRS was used to assess psychiatric symptoms. The subjects were also systematically questioned regarding the adverse events described in an interview form following GE treatment. An intension-to-treat analysis including all patients enrolled in the present study was completed.ResultsOne patient declined to participate further in the study on the third day after the start of treatment. Eight patients thus completed the entire trial (male: 2, female: 6, age [mean±SD]: 38.8±11.6 years). The average dosage of GE was 567 mg/day (300 mg/day [n=1], 600 mg/day [n=8]). The BARS global akathisia score significantly decreased after 1 and 2 weeks of treatment when compared to baseline (P=0.01 and P=0.01, respectively). There were no significant differences in BPRS score 1 or 2 weeks after the start of treatment. No serious adverse events occurred.ConclusionGE has therapeutic potential for antipsychotics-induced akathisia. No additional risk of GE use for the management of akathisia was indicated.

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Section: Discussionmentioning

confidence: 99%

Gabapentin enacarbil for antipsychotic induced akathisia in schizophrenia patients: a pilot open-labeled study

Takeshima¹,

Ishikawa

Kanbayashi³

et al. 2018

NDT

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“…Common side effects include sedation, weight gain and increased appetite. Recent studies have shown that mirtazapine is useful for the treatment of AIAA [Poyurovsky and Weizman, 2001a;Wilson, 2005;Ranjan et al 2006;Poyurovsky et al 2003Poyurovsky et al , 2006Poyurovsky et al , 2014, although a few case reports of akathisia, both acute and tardive, induced by mirtazapine have been reported [Girishchandra et al 2002;Gulsun and Doruk, 2008;Ozyildirim and Kosecioglu, 2009;Markoula et al 2010]. As the effect of first-line agents for AIAA is variable, we reviewed existing literature to identify if enough evidence is available for mirtazapine.…”

Section: Introductionmentioning

confidence: 99%

Mirtazapine for antipsychotic-induced acute akathisia: a systematic review and meta-analysis of randomized placebo-controlled trials

Praharaj

Kongasseri

Behere

et al. 2015

Therapeutic Advances in Psychopharmacology

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“…[ 3 ] Intriguingly, this medication has been associated with occurrence of akathisia as an adverse effect. [ 4 ] Here we report the case of a patient with depressive illness who developed mirtazapine induced akathisia which was relieved by discontinuing the drug and by substituting it with another antidepressant.…”

mentioning

confidence: 99%

“…It has been hypothesized that the beneficial effect of this medication in akathisia is due to 5HT2A antagonism while the α2 blockade might be responsible for akathisia. [ 3 4 6 ] Thus, even though mirtazapine is considered as a therapeutic option in antipsychotic induced akathisia, clinicians also need to be aware that it can produce this distressing extrapyramidal adverse effect.…”

mentioning

confidence: 99%