Miscellaneous Blood Product Usage

Holowaychuk, Marie K.; Yagi, Kenichiro

doi:10.1002/9781118933053.ch8

Cited by 3 publications

(2 citation statements)

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“…In addition, an assumption of initial blood volume is necessary to account for sampling losses ( 17 ), which meant having to introduce more uncertainties and potential source of error into the model. Although the degree of error associated with the use of varying initial blood volume is acceptable in humans ( 26 , 37 ), the feline blood volume reported in the current veterinary literature is based on a small number of past experiments ( 63 , 69 , 70 ) and ranges widely from 40 to 66 mL/kg ( 71 , 72 ) depending on whether cats are splenectomised or not ( 63 , 70 ). The plasma dilution-time curve of 3 randomly selected experimental data sets did not differ substantively following correction of Hb loss.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Distribution and Elimination of Balanced Isotonic Crystalloid, 5% Hypertonic Saline, and 6% Tetrastarch 130/0.4 Using Volume Kinetic Modeling and Analysis in Healthy Conscious Cats

et al. 2020

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This prospective, randomized, blinded, interventional cross-over study investigated the distribution, elimination, plasma volume expansion, half-life, comparative potency, and ideal fluid prescription of three commonly prescribed intravenous (IV) fluids in 10 healthy conscious cats using volume kinetic analysis that is novel to veterinary medicine. Each cat received 20 mL/kg of balanced isotonic crystalloid (PLA), 3.3 mL/kg of 5% hypertonic saline (HS), and 5 mL/kg of 6% tetrastarch 130/0.4 (HES) over 15 min on separate occasions. Hemoglobin concentration, red blood cell count, hematocrit, heart rate, and blood pressure were measured at baseline, 5, 10, 15, 20, 30, 40, 50, 60, and every 15 min until 180 min. Urine output was estimated every 30 min using point-of-care bladder ultrasonography. Plasma dilution derived from serial hemoglobin concentration and red blood cell count served as input variables for group and individual fluid volume kinetic analyses using a non-linear mixed effects model. In general, the distribution of all IV fluids was rapid, while elimination was slow. The half-lives of PLA, HS, and HES were 49, 319, and 104 min, respectively. The prescribed fluid doses for PLA, HS, and HES resulted in similar peak plasma volume expansion of 27–30%. The potency of HS was 6 times higher than PLA and 1.7 times greater than HES, while HES was 3.5 times more potent than PLA. Simulation of ideal fluid prescriptions to achieve and maintain 15 or 30% plasma volume expansion revealed the importance of a substantial reduction in infusion rates following initial IV fluid bolus. In conclusion, volume kinetic analysis is a feasible research tool that can provide data on IV fluid kinetics and body water physiology in cats. The rapid distribution but slow elimination of IV fluids in healthy conscious cats is consistent with anecdotal reports of fluid overload susceptibility in cats and warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Distribution and Elimination of Balanced Isotonic Crystalloid, 5% Hypertonic Saline, and 6% Tetrastarch 130/0.4 Using Volume Kinetic Modeling and Analysis in Healthy Conscious Cats

et al. 2020

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“…Another software testing tool that seeks to be expressive and easy to use is Should.js [18], an assertion library for Javascript that lets the user chain together english phrases that make testing clear and easy to understand. Should.js is a clever and useful library that helps to bridge the gap between computers and their human operators but remains a technical tool that would be difficult for non-programmers to use and understand.…”

Section: Related Workmentioning

confidence: 99%

Untitled

2018

IJCSITCE

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Modern IP networks are complex entities that require constant maintenance and care. Similarly, constructing a new network comes with a high amount of upfront cost, planning, and risk. Unlike the disciplines of software and hardware engineering, networking and IT professionals lack an expressive and useful certification language that they can use to verify that their work is correct. When installing and maintaining networks without a standard for describing their behavior, teams find themselves prone to making configuration mistakes. These mistakes can have real monetary and operational efficiency costs for organizations that maintain large networks.In this research, the Network Certification Description Language (NETCDL) is proposed as an easily human readable and writeable language that is used to describe network components and their desired behavior. The complexity of the grammar is shown to rank in the top 5 out of 31 traditional computer language grammars, as measured by metrics suite. The language is also shown to be able to express the majority of common use cases in network troubleshooting. A workflow involving a certifier tool is proposed that uses NETCDL to verify network correctness, and a reference certifier design is presented to guide and standardize future implementations.

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