Miscible Polymer Blends

Goh, S. H.

doi:10.1007/978-94-007-6064-6_24

Cited by 11 publications

(11 citation statements)

References 1,937 publications

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“…This value was in the same order with the one reported by Messin et al who obtained a dioxygen permeability of 0.196 Barrer in the same experimental condition [ 42 ]. This value was higher than common polyesters such as PET and PHBV which have water permeability of respectively, 0.09 Barrer [ 66 ] and 0.031 Barrer [ 67 ] but was slightly smaller than the value found on PLA of 0.23 Barrer [ 58 ]. As in case of water permeability analysis, in the tested range of water activity,

increased linearly as the water activity increased and can be explained by a plasticization of the PBS matrix due to the presence of water molecules sorbed by the polymer which tended to decrease the cohesive density energy of the films.…”

Section: Resultsmentioning

confidence: 56%

“…The obtained value of

for neat PBS matrix at a w = 1 was equal to 2518 Barrer, in good agreement with this reported in the same condition by Charlon et al (2616 Barrer) [ 3 ]. The obtained value was higher than those of common polyesters such as PLA, PET and PHBV 1957 Barrer [ 58 ], 150 Barrer [ 66 ] and 149 Barrer [ 67 ], respectively. In the tested range of water activity,

increased linearly as the water activity increased.…”

Section: Resultsmentioning

confidence: 84%

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Improvement of Barrier Properties of Biodegradable Polybutylene Succinate/Graphene Nanoplatelets Nanocomposites Prepared by Melt Process

2021

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Polybutylene Succinate (PBS)/Graphene nanoplatelets (GnP) nanocomposites over a range of GnP from 0 to 1.35 wt.%. were prepared by a melt process. A mixture of individual graphene nanosheets and aggregates was obtained by the addition of GnP in the PBS matrix. The presence of these fillers did not significantly modify the morphology, crystalline microstructure of the matrix or its thermal stability. However, a slight reinforcement effect of PBS was reported in the presence of GnP. The water sorption isotherm modelling with Guggenheim, Andersen and De Boer (GAB) equation and Zimm-Lundberg theory allowed a phenomenological analysis at the molecular scale. The presence of GnP did not modify the water sorption capacity of the PBS matrix. From a kinetic point of view, a decrease of the diffusion coefficient with the increasing GnP content was obtained and was attributed to a tortuosity effect. The influence of water activity was discussed over a range of 0.5 to 1 and 0 to 0.9 for water and dioxygen permeability. Improvement of the barrier properties by 38% and 35% for water and dioxygen permeability respectively were obtained.

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Section: Resultsmentioning

confidence: 56%

“…The obtained value of

increased linearly as the water activity increased.…”

Section: Resultsmentioning

confidence: 84%

Improvement of Barrier Properties of Biodegradable Polybutylene Succinate/Graphene Nanoplatelets Nanocomposites Prepared by Melt Process

2021

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“…Since it is known that temperature and processing method can have an important effect on the miscibility behaviour of a polymer blend [ 24 ], both PEtOx/PPrOx (1/1) and PEtOx/PsecBuOx (1/1) were processed at three different temperatures: 45 °C (spray drying), 35 °C (spray drying) and 25 °C (electrospraying). Electrospraying was selected as a processing method since it allowed efficient solvent evaporation at 25 °C, which could not be achieved via spray drying.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Whether or not a polymer blend is miscible, depends not only on specific interactions such as ion-ion, ion-dipole, dipole-dipole and hydrogen bonds, but also on the temperature at which the polymer blend is processed and stored [ 24 ]. Blends might demonstrate lower or upper critical solution temperature behaviour [ 24 ]. In order to assess the effect of the temperature at which the blends were processed, different process conditions and manufacturing techniques were investigated for both the PEtOx/PPrOx and the PEtOx/PsecBuOx blends.…”

Section: Introductionmentioning

confidence: 99%

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Unravelling the Miscibility of Poly(2-oxazoline)s: A Novel Polymer Class for the Formulation of Amorphous Solid Dispersions

et al. 2020

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Water-soluble polymers are still the most popular carrier for the preparation of amorphous solid dispersions (ASDs). The advantage of this type of carrier is the fast drug release upon dissolution of the water-soluble polymer and thus the initial high degree of supersaturation of the poorly soluble drug. Nevertheless, the risk for precipitation due to fast drug release is a phenomenon that is frequently observed. In this work, we present an alternative carrier system for ASDs where a water-soluble and water-insoluble carrier are combined to delay the drug release and thus prevent this onset of precipitation. Poly(2-alkyl-2-oxazoline)s were selected as a polymer platform since the solution properties of this polymer class depend on the length of the alkyl sidechain. Poly(2-ethyl-2-oxazoline) (PEtOx) behaves as a water-soluble polymer at body temperature, while poly(2-n-propyl-2-oxazoline) (PPrOx) and poly(2-sec-butyl-2-oxazoline) (PsecBuOx) are insoluble at body temperature. Since little was known about the polymer’s miscibility behaviour and especially on how the presence of a poorly-water soluble drug impacted their miscibility, a preformulation study was performed. Formulations were investigated with X-ray powder diffraction, differential scanning calorimetry (DSC) and solid-state nuclear magnetic resonance spectroscopy. PEtOx/PPrOx appeared to form an immiscible blend based on DSC and this was even more pronounced after heating. The six drugs that were tested in this work did not show any preference for one of the two phases. PEtOx/PsecBuOx on the other hand appeared to be miscible forming a homogeneous blend between the two polymers and the drugs.

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Advances in Additive Manufactured Scaffolds Mimicking the Osteochondral Interface

Beeren,

Dijkstra,

Mota

et al. 2024

Advanced NanoBiomed Research

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Architectural, compositional, and mechanical gradients are present in many interfacial tissues in the body. Yet desired for regeneration, the recreation of these complex natural gradients in porous scaffolds remains a challenging task. Additive manufacturing (AM) has been highlighted as a technology to fabricate constructs to regenerate interfacial tissues. Integration of different types of gradients, which can be physical, mechanical, and/or biochemical, shows promise to control cell fate and the regeneration process in a spatial controlled manner. One of the most studied tissue interfaces is the osteochondral unit which connects cartilage to bone. This tissue is often damaged because of trauma or ageing, leading to osteoarthritis; a degenerative disease and a major cause of disability worldwide. Therefore, in view of osteochondral (OC) regeneration, a state‐of‐the‐art overview of current approaches is presented to manufacture gradient scaffolds prepared by AM techniques. The focus is on thermoplastic, hydrogel, and hybrid scaffolds comprising gradients that induce biomimicry by their physical and biological properties. The effect of these different systems on OC tissue formation in‐vitro and in‐vivo is addressed. Finally, an outlook on current trends of dynamic materials is provided, including proposals on how these materials could improve the mimicry of scaffolds applied for OC regeneration.

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Miscible Polymer Blends

Cited by 11 publications

References 1,937 publications

Improvement of Barrier Properties of Biodegradable Polybutylene Succinate/Graphene Nanoplatelets Nanocomposites Prepared by Melt Process

Improvement of Barrier Properties of Biodegradable Polybutylene Succinate/Graphene Nanoplatelets Nanocomposites Prepared by Melt Process

Unravelling the Miscibility of Poly(2-oxazoline)s: A Novel Polymer Class for the Formulation of Amorphous Solid Dispersions

Advances in Additive Manufactured Scaffolds Mimicking the Osteochondral Interface

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