Misdiagnosis Murder: Disguised TB or Lung Cancer?

Vaghasiya, Kalpesh; Sharma, Ankur; Verma, Rajkumar

doi:10.17140/prrmoj-3-e006

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…There is no sufficient evidence supporting the introduction of population-based screening for lung cancer in public health services. [369][370][371][372][373][374][375][376] However, many centres do the screening programme like the Dharamshila Narayana Superspeciality Hospital (A Unit of Dharamshila Cancer Foundation and Research Centre), New Delhi and others. Through this programme, the center provides low-dose CT screening for people who were between the ages of 55 and 74, and have smoked 30 or more pack years.…”

Section: Screening Of Lung Cancer In Indiamentioning

confidence: 99%

Lung Cancer in India–Part I

Behera¹

2022

The Indian Journal of Chest Diseases and Allied Sciences

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Section: Screening Of Lung Cancer In Indiamentioning

confidence: 99%

Lung Cancer in India–Part I

Behera¹

2022

The Indian Journal of Chest Diseases and Allied Sciences

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“… 8 , 19 , 39 Misdiagnosis of lung ca as pulmonary tuberculosis appears significant in most African countries where TB is endemic, obscuring the true numbers of other lung diseases such as lung cancer. 40 Anecdotal evidence in our setting shows that many lung cancer cases would have completed or been initiated on PTB treatment before their referral. Thus, it is unsurprising that the predominant clinical staging of the disease at presentation was stage IV (advanced disease) in close to 88% of the study cohort, which only casts a poor shadow on patient survival curves.…”

Section: Discussionmentioning

confidence: 93%

A three-year review of lung cancer patient characteristics in a tertiary hospital

S. Afriyie-Mensah,

Kwarteng,

Tetteh

et al. 2023

gmj

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Objective: The study sought to determine clinical characteristics and histologic subtypes of a cohort of lung cancer patients in a tertiary facility.Design: Retrospective review of the medical records of histology-confirmed lung cancer cases at the respiratory clinic over a 3-year period.Setting: Respiratory Clinic, Korle-Bu Teaching Hospital, Accra, GhanaParticipants: All adult patients with histologically diagnosed lung cancer were enrolled.Main outcome measures: Lung cancer histological typesResults: The proportion of lung cancer cases was 12.4%. The majority were women (57.8%) and the mean age at diagnosis was 55.8±16.0 years. The patients were predominantly non-smokers (61%). Common symptoms were chronic cough and chest pain. More than two-thirds of the cases presented in clinical stages III and IV with the pre-dominant histological subtype being adenocarcinoma in smokers and non-smokers. Genetic testing for epidermal growth factor receptor (EGFR) and Anaplastic Lymphoma kinase (ALK) mutations were largely absent.Conclusions: The majority of lung cancer patients presented late with advanced disease. Adenocarcinoma was the predominant histological subtype in a predominantly non-smoking population, with an increased prevalence among women less than 60 years. This should encourage testing for genetic mutations to improve patient survival.

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“…There was no family history of breast cancer. There was no fever, no weight loss, no chest pain but he cancers misdiagnosed as SN PTB [15][16][17][18]. These cases should have been promptly referred for further expert assessment.…”

Section: Casementioning

confidence: 99%

Smear Negative Pulmonary Tuberculosis Is a Distinct Clinical Entity, Not a "Misdiagnosis Waste Basket"

E¹,

O²,

A³

et al. 2022

Int J Respir Pulm Med

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Background: PTB can mimic many chronic lung diseases resulting in misdiagnosis with serious consequences. Objectives:To appraise all SN PTB patients who were referred to us from lower health facilities after unsuccessful treatment in order to confirm the appropriate diagnosis. Methods:A cross sectional study at the pulmonary section of our hospital. Results:The median age of our patients was 46 with interquartile range of 32 to 54 years. The commonest presenting symptom was difficulty in breathing which was present in almost 90% of them (30 out of 34), cough was present in 24 with sputum production in 22 while haemoptysis was reported in 3. All the 5 patients with malignancy reported chest pain. Sixty eight percent of the patients were referred from Peripheral TB DOT centers and sputum smear tests were done in 82% of them while radiologic tests were done in less than 50% of the patients. The final diagnoses include COPD, malignancy, sarcoidosis, interstitial lung diseases and fungal infection among others. Conclusion: Many lung diseases are misdiagnosed as SN PTB because of similarity in clinical presentation, overreliance on diagnostic test with low TB detection and non adherence to local guidelines. We advocate for WHO-recommended rapid molecular test for all our suspected TB cases and prompt referral of difficult to diagnose cases.

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Misdiagnosis Murder: Disguised TB or Lung Cancer?

Cited by 6 publications

References 5 publications

Lung Cancer in India–Part I

Lung Cancer in India–Part I

A three-year review of lung cancer patient characteristics in a tertiary hospital

Smear Negative Pulmonary Tuberculosis Is a Distinct Clinical Entity, Not a "Misdiagnosis Waste Basket"

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