Background
Elderly patients are at a four-fold higher risk of adverse drug events (ADEs) and drug related hospitalization. Hospitalization of an elderly patient is often preceded by geriatric syndromes, like falls or delirium.
Objectives
The primary aim of this study is to investigate whether geriatric syndromes were associated with ADEs in acutely admitted elderly patients.
Methods
Consecutive medical patients, aged 65 years or more, and were acutely admitted, were enrolled. An initial multidisciplinary evaluation was completed and baseline characteristics were collected. A fall before admission was retrieved from medical charts. Delirium was determined by the Confusion Assessment Method.
Results
A total of 641 patients were included. Over 25% had an ADE present at admission, 26% presented with delirium and 12% with a fall. Delirium was associated with the use of antidepressants, antipsychotics, and antiepileptics. In all ADEs (N=167), ADE was associated with a fall, with NSAIDs or diuretics, but not with pre-existing functioning, delirium or older age. For ADEs involving psychoactive medication (N=35), an association was found between delirium, fall, opioids and antipsychotics in bivariate analyses. A fall just before hospitalization (OR 3.69 [95% CI 1.41–9.67]), antipsychotics (OR 3.70 [95% CI 1.19–11.60]) and opioids (OR 14.57 [95% CI 2.02–105.30]) remained independently associated with an ADE involving psychoactive medication.
Conclusion
This prospective study demonstrated that in a cohort of elderly hospital patients a fall before admission and prevalent delirium are associated with several pharmacological groups and/or with ADE-related hospital admission.