Misleading Features of Bone Marrow Involvement by Peripheral T-Cell Lymphomas

Gaulard, Philippe; Hoeller, Sylvia

doi:10.1007/978-1-4471-4174-7_14

Cited by 1 publication

(2 citation statements)

References 23 publications

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“…Eosinophils are always present in the TME of AITL albeit in differential numbers, as evidenced by blood hypereosinophilia in around 30%-50% of AITL subjects (169). It has also been reported that bone marrow hyperplasia along with eosinophilia is common in AITL (159). The link between eosinophilic infiltrates present in the tumor biopsies and CCL17/TRAC mRNA expression on mononuclear cells present in the TME has been reported (170).…”

Section: Tumor Microenvironment In Peripheral T-cell Lymphomas and Cy...mentioning

confidence: 98%

“…At the cellular level, tumor cells of AITL vary in size (small to medium) and are mature

CD4+ and CD8+ T cells ( 157 , 158 ). Since these AITL cells are derived from Tfh cells, they continue to express various Tfh-associated proteins like BCL6, ICOS, C-MAF, CD200, CXCL13, and SAP ( 157 , 159 ). In the AITL neoplastic cells, neutral endo-peptidase CD10 is also observed in variable proportions ( 160 ).…”

Section: Tumor Microenvironment Of T-cell Lymphoma and The Role Of Cy...mentioning

confidence: 99%

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Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Yadav,

Uikey,

Rathore

et al. 2023

Front. Oncol.

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T cells are an important component of adaptive immunity and T-cell-derived lymphomas are very complex due to many functional sub-types and functional elasticity of T-cells. As with other tumors, tissues specific factors are crucial in the development of T-cell lymphomas. In addition to neoplastic cells, T- cell lymphomas consist of a tumor micro-environment composed of normal cells and stroma. Numerous studies established the qualitative and quantitative differences between the tumor microenvironment and normal cell surroundings. Interaction between the various component of the tumor microenvironment is crucial since tumor cells can change the microenvironment and vice versa. In normal T-cell development, T-cells must respond to various stimulants deferentially and during these courses of adaptation. T-cells undergo various metabolic alterations. From the stage of quiescence to attention of fully active form T-cells undergoes various stage in terms of metabolic activity. Predominantly quiescent T-cells have ATP-generating metabolism while during the proliferative stage, their metabolism tilted towards the growth-promoting pathways. In addition to this, a functionally different subset of T-cells requires to activate the different metabolic pathways, and consequently, this regulation of the metabolic pathway control activation and function of T-cells. So, it is obvious that dynamic, and well-regulated metabolic pathways are important for the normal functioning of T-cells and their interaction with the microenvironment. There are various cell signaling mechanisms of metabolism are involved in this regulation and more and more studies have suggested the involvement of additional signaling in the development of the overall metabolic phenotype of T cells. These important signaling mediators include cytokines and hormones. The impact and role of these mediators especially the cytokines on the interplay between T-cell metabolism and the interaction of T-cells with their micro-environments in the context of T-cells lymphomas are discussed in this review article.

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Section: Tumor Microenvironment In Peripheral T-cell Lymphomas and Cy...mentioning

confidence: 98%

“…At the cellular level, tumor cells of AITL vary in size (small to medium) and are mature

Section: Tumor Microenvironment Of T-cell Lymphoma and The Role Of Cy...mentioning

confidence: 99%

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Yadav,

Uikey,

Rathore

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Misleading Features of Bone Marrow Involvement by Peripheral T-Cell Lymphomas

Cited by 1 publication

References 23 publications

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

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