Mismatch negativity impairment associated with alcohol consumption in chronic alcoholics: A scalp current density study

Understanding alcohol use disorders with neuroelectrophysiology

“…Grau and colleagues (2001) found that, while the MMN component is abolished with more demanding tasks in chronic alcoholics, it is present in normal controls. It has been suggested that the mechanisms to detect auditory differences may be reorganized in the brains of alcoholics, as revealed by lower scalp current densities in left frontal and right temporal areas during MMN in alcoholics (Marco-Pallares et al, 2007). However, no group differences in MMN amplitude have been reported in young HR offspring (van der Stelt et al, 1997; Rodriguez Holguin et al, 1998).…”

Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

“…These latter findings appear to support the role of the NMDA receptor in vulnerability toward heavy drinking, with a higher MMN representing a higher NMDA receptor output, suggesting a higher dose of alcohol would be necessary to achieve NMDA blockade and subsequent intoxication. However, not all MMN findings align with the NMDA-alcohol model, with some studies finding no differences in MMN between individuals with alcohol dependence and controls (Fein et al, 2004a;Fein et al, 2004b;Marco-Pallares et al, 2007).…”

Targeting electroencephalography for alcohol dependence: A narrative review

“…Grau et al found that when the memory test interval was 0.4 s, MMN was not significantly different between the patient group and the healthy control group, while MMN was not observed in the patient group when the memory test interval was 5.0 s, which suggests that auditory memory is impaired in alcohol‐dependent patients, while the mechanism for automatic detection of stimulus changes is still preserved 37 . Analysis of scalp current density (SCD) of MMN found that the left frontal lobe and right anterior temporal/posterior temporal region of the patients had decreased SCD, which indicates that the amount of alcohol consumed was negatively correlated with SCD intensity in these brain regions, and the duration of abstinence was positively correlated with SCD intensity 38 . MMN can assist the clinical evaluation of alcohol dependence by reflecting the degree of neurological impairment.…”

“… 37 Analysis of scalp current density (SCD) of MMN found that the left frontal lobe and right anterior temporal/posterior temporal region of the patients had decreased SCD, which indicates that the amount of alcohol consumed was negatively correlated with SCD intensity in these brain regions, and the duration of abstinence was positively correlated with SCD intensity. 38 MMN can assist the clinical evaluation of alcohol dependence by reflecting the degree of neurological impairment.…”