Mismatch negativity (MMN) reduction in schizophrenia—Impaired prediction-error generation, estimation or salience?

Todd, Juanita; Michie, Patricia T.; Schall, Ulrich; Ward, Philip B.; Catts, Stanley V.

doi:10.1016/j.ijpsycho.2011.10.003

Cited by 88 publications

(75 citation statements)

References 148 publications

(157 reference statements)

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“…A major theme in this work is the failed suppression of attention to familiar or irrelevant information/stimuli in the environment, leading to aberrant salience of objects and associations [82,83] -or, to reverse the terminology, excessive attention to information that is highly familiar or irrelevant. A number of neurocognitive models and experimental paradigms have produced findings consistent with this view, including the memoryprediction model of cortical function [48,84,85], the salience dysregulation model based on dopamine system abnormalities [55,57,82], mismatch negativity reduction [86], latent inhibition [54,87,88], and Corlett's model of ketamine as a pharmacological model of psychosis [89,90]. Also, Hemsley [58,59,91] and Sass [9] drew on findings regarding malfunction in the hippocampus-based "comparator" system in schizophrenia, proposing that this dysfunction may result in an automatic, hyperreflexive awareness that disrupts the tacit/focal structure essential to normal experience of basic selfhood.…”

Section: Possible Phenomenological Correlatesmentioning

confidence: 95%

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Nelson

Sass

2017

Current Problems of Psychiatry

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Phenomenological research indicates that disturbance of the basic sense of self may be a core phenotypic marker of schizophrenia spectrum disorders. Basic self-disturbance refers to disruption of the sense of ownership of experience and agency of action and is associated with a variety of anomalous subjective experiences. Little is known about the neurocognitive correlates of basic selfdisturbance. In this paper, we review recent phenomenological and neurocognitive research and point to a convergence of these approaches around the concept of self-disturbance. Specifically, we propose that subjective anomalies associated with basic selfdisturbance may be associated with: 1. source monitoring deficits, which may contribute particularly to disturbances of "ownership" and "mineness" (the phenomenological notion of presence) and 2. aberrant salience, and associated disturbances of memory, prediction, and attention processes, which may contribute to hyper-reflexivity, disturbed "grip" or "hold" on the perceptual and conceptual field, and disturbances of intuitive social understanding ("common sense"). These two streams of research are reviewed in turn before considering ways forward in integrative models, particularly regarding the role of early neurodevelopmental disturbances, primary versus secondary disturbances, and the state versus trait nature of such pathology. Empirical studies are required in a variety of populations in order to test the proposed associations between phenomenological and neurocognitive aspects of self-disturbance in schizophrenia. An integration of findings across the phenomenological and neurocognitive domains would represent a significant advance in the understanding of schizophrenia and possibly enhance early identification and intervention strategies.

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Section: Possible Phenomenological Correlatesmentioning

confidence: 95%

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Nelson

Sass

2017

Current Problems of Psychiatry

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“…This is well in line with deficits in auditory MMN which have been widely explored for more than three decades, and since the first report of an aMMN deficit (Shelley et al, 1991), there have been 256 articles published addressing this issue (source PubMed, "MMN" schizophrenia, May 2015). Most of these studies showed an aMMN amplitude reduction in schizophrenia (Todd, Michie, Schall, Ward, & Catts, 2012;Umbricht & Krljes, 2005) and, moreover, this sensory deficit was associated with the impaired daily functioning of the patients (Todd, Harms, Schall, & Michie, 2013). The aMMN sensitivity to the sensory deficit depends on the type of deviance used, e.g., pitch, intensity, or duration, with the duration violation being the most sensitive test as shown by a meta-analysis of 32 reports (Umbricht & Krljes, 2005).…”

Section: Summary Of Vmmn Studies In Schizophreniamentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

122

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The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensor...

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“…These factors reflect the quantification of the error in a literal sense (see Todd et al 2012 for discussion).…”

Section: Mismatch Negativitymentioning

confidence: 99%

What controls gain in gain control? Mismatch negativity (MMN), priors and system biases

et al. 2013

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Mismatch negativity (MMN) reduction in schizophrenia—Impaired prediction-error generation, estimation or salience?

Cited by 88 publications

References 148 publications

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

What controls gain in gain control? Mismatch negativity (MMN), priors and system biases

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