Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis

Solís-Vivanco, Rodolfo; Mondragón‐Maya, Alejandra; León-Ortíz, Pablo; Rodríguez-Agudelo, Yaneth; Cadenhead, Kristin S.; Fuente‐Sandoval, Camilo de la

doi:10.1016/j.schres.2014.07.009

Cited by 38 publications

(23 citation statements)

References 52 publications

(71 reference statements)

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“…Such studies have demonstrated consistent reductions of MMN in CHR individuals, albeit of smaller magnitude (typically 0.6-0.8 SDs vs. controls) than those observed in schizophrenia(Atkinson et al, 2012; Bodatsch et al, 2011; Higuchi et al, 2013; Jahshan et al, 2012; Perez et al, 2013; Shaikh et al, 2012; Solis-Vivanco et al, 2014). In addition, reductions in MMN amplitudes significantly predict conversion to psychosis among CHR individuals(Atkinson et al, 2012; Bodatsch et al, 2011; Higuchi et al, 2013; Perez et al, 2013; Shaikh et al, 2012).…”

Section: Introductionmentioning

confidence: 86%

Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis

Carrión

Cornblatt²,

McLaughlin

et al. 2015

Schizophrenia Research

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Background There is a growing recognition that individuals at clinical high risk need intervention for functional impairments, along with emerging psychosis, as the majority of clinical high risk (CHR) individuals show persistent deficits in social and role functioning regardless of transition to psychosis. Recent studies have demonstrated reduced reading ability as a potential cause of functional disability in schizophrenia, related to underlying deficits in generation of mismatch negativity (MMN). The present study extends these findings to subjects at CHR. Methods The sample consisted of 34 CHR individuals and 33 healthy comparisons subjects (CNTLs) from the Recognition and Prevention (RAP) Program at the Zucker Hillside Hospital in New York. At baseline, reading measures were collected, along with MMN to pitch, duration, and intensity deviants, and measures of neurocognition, and social and role (academic/work) functioning. Results CHR subjects showed impairments in reading ability, neurocognition, and MMN generation, relative to CNTLs. Lower-amplitude MMN responses were correlated with worse reading ability, slower processing speed, and poorer social and role functioning. However, when entered into a simultaneous regression, only reduced responses to deviance in sound duration and volume predicted poor social and role functioning, respectively. Conclusions Deficits in reading ability exist even prior to illness onset in schizophrenia and may represent a decline in performance from prior abilities. As in schizophrenia, deficits are related to impaired MMN generation, suggesting specific contributions of sensory-level impairment to neurocognitive processes related to social and role function.

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Section: Introductionmentioning

confidence: 86%

Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis

Carrión

Cornblatt²,

McLaughlin

et al. 2015

Schizophrenia Research

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“…43-47 The SDs from 1 article could not be ascertained for the first-episode or control group. 48 The remaining 14 studies were included in the analysis, 7,49-61 and the results from these studies are summarized in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Mismatch Negativity in First-Episode Schizophrenia

2016

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Mismatch negativity (MMN) to deviant stimuli is robustly smaller in individuals with chronic schizophrenia compared with healthy controls (Cohen’s d > 1.0 or more), leading to the possibility of MMN being used as a biomarker for schizophrenia. However, there is some debate in the literature as to whether MMN is reliably reduced in first-episode schizophrenia patients. For the biomarker to be used as a predictive marker for schizophrenia, it should be reduced in the majority of cases known to have the disease, particularly at disease onset. We conducted a meta-analysis on the fourteen studies that measured MMN to pitch or duration deviants in healthy controls and patients within 12 months of their first episode of schizophrenia. The overall effect size showed no MMN reduction in first-episode patients to pitch-deviants (Cohen’s d < 0.04), and a small-to-medium reduction to duration-deviants (Cohen’s d = 0.47). Together, this indicates that pitch-deviant MMN is not a candidate biomarker for schizophrenia prediction, while duration-deviant MMN may hold some promise, albeit nearly a third as large an effect as in chronic schizophrenia. Potential causes for discrepancies between studies are discussed.

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“…Decreased auditory MMN (Brockhaus-Dumke et al, 2005;Atkinson et al, 2012;Solis-Vivanco et al, 2014) and its magnetic counterpart (Shin et al, 2009) have been found in patients in their first episode of psychosis as well as individuals at high risk for psychosis. Furthermore, there is increasing evidence from longitudinal electrophysiological studies that MMN can be useful to predict the onset of psychosis.…”

Section: Using Mmn To Predict Psychosismentioning

confidence: 99%

Elementary sensory deficits in schizophrenia indexed by impaired visual mismatch negativity

Farkas¹,

Stefanics²,

Marosi³

et al. 2015

Schizophrenia Research

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Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis

Cited by 38 publications

References 52 publications

Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis

Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis

Mismatch Negativity in First-Episode Schizophrenia

Elementary sensory deficits in schizophrenia indexed by impaired visual mismatch negativity

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