Mismatched Hl-a Haplotypes With Antigens Hl-A1, 3, and 11 Associated With Excellent Renal Allograft Function

A critical factor limiting the availability of histocompatible platelet transfusions for alloimmunized, thrombocytopenic patients is the large pool of HLA-typed donors needed to procure platelets perfectly matched for HLA antigens. We have, therefore, investigated the effectiveness of platelets obtained from donors having lesser degrees of histocompatibility. In 421 transfusions administered to 59 alloimmunized patients who were refractory to "random donor" platelets, it was found that platelets mismatched for 1 or 2 "cross-reactive" HLA antigens were in most instances as effective in increasing circulating platelet levels as perfectly matched platelets. A significant number of patients also responded to platelets from donors selectively mismatched for non-cross-reactive HLA antigens. The latter group had a significantly reduced frequency of the antigen HLA-A2 (13%) in comparison to the total patient population (49%). Use of donors whose HLA antigens are serologically cross-reactive with those of alloimmunized patients provides approximately 10 times as many prospective donors as does selection based on matching for HLA and simplifies the procurement of hemostatically effective platelets for such patients.

show abstract

Successful transfusion of platelets “mismatched” for HLA antigens to alloimmunized thrombocytopenic patients

Duquesnoy

et al. 1977

View full text Add to dashboard Cite

show abstract

Histocompatibility testing in intrafamilial renal transplantation

Cohen

Gregory

Early

et al. 1973

Urology

View full text Add to dashboard Cite

The New Serology of Histocompatibility Testing and Its Significance in Human Renal Transplantation

Braun

1976

Urologic Clinics of North America

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Mismatched Hl-a Haplotypes With Antigens Hl-A1, 3, and 11 Associated With Excellent Renal Allograft Function

Cited by 4 publications

References 0 publications

Successful transfusion of platelets “mismatched” for HLA antigens to alloimmunized thrombocytopenic patients

Successful transfusion of platelets “mismatched” for HLA antigens to alloimmunized thrombocytopenic patients

Histocompatibility testing in intrafamilial renal transplantation

The New Serology of Histocompatibility Testing and Its Significance in Human Renal Transplantation

Contact Info

Product

Resources

About