Misoprostol and congenital malformations

Early Pregnancy Termination with Oral Mifepristone and Vaginal Misoprostol

“…Although there are no confirmed reports of congenital anomalies after the administration of mifepristone, there are reports of congenital malformation after the use of misoprostol alone 21,22,23 . These malformation includes scalp or skull defects, cranial nerve palsies and limb defect 24,25 . In our study there was no case leading to continuation of pregnancy following medical termination.…”

Misoprostol: a solução não é tão simples

“…Os primeiros trabalhos evidenciando o uso indiscriminado do misoprostol, como abortivo no Brasil, foram realizados pelo Grupo de Prevenção ao Uso Indevido de Medicamentos da Universidade Federal do Ceará (GPUIM), em 1990-94 [2][3][4][5] . Foi também no Ceará que se detectaram os primeiros casos de malformação em bebês expostos ao misoprostol in utero 5 .…”

“…Foi também no Ceará que se detectaram os primeiros casos de malformação em bebês expostos ao misoprostol in utero 5 . O fármaco é hoje classificado pela FDA entre as drogas teratogênicas, e este efeito adverso é citado em todas as fontes bibliográficas importantes da área de medicamentos.…”

Congenital Anomalies Associated With Failed Misoprostol Termination Of Pregnancy

“…2 Three cases of unusual congenital malformations of the scalp and cranium with exposure of the cerebrum and duramater occurred in newborns exposed to misoprostol in first trimester over a period of 5-months in Fortaleza, Brazil. 3 Our patient had been exposed to 800-mg oral misoprostol in the first trimester of pregnancy. In the absence of a relevant family history and otherwise being a young and healthy nondiabetic woman who had not taken other abortifacient drugs, it can easily be speculated that the cause of these similar vascular disruption type of congenital anomalies here was a fairly high dose of oral misoprostol as is being reported in the literature.…”

“…2 Frontotemporal, frontal bone and scalp defects have been reported from Brazil. 3 These anomalies are thought to result from vascular disruption induced in the embryo or foetus by misoprostol. 4,5 Misoprostol has been introduced for only last few years in Pakistan as a cervical ripening agent for late first trimester and mid trimester pregnancy terminations mainly for therapeutic reasons.…”