Missing Y Chromosome in 2 Patients with Chronic Myelocytic Leukemia

Abstract

2 cases of chronic myelocytic leukemia (CML) without Y chromosome are reported. One is a 45-year-old man with Philadelphia-positive CML, and the other a 74-year-old patient with Philadelphia-negative CML. Cytogenetic analysis of bone marrow and peripheral blood cultures with and without PHA stimulation was carried out. The Philadelphia-positive patient died after 15 months, whereas in the case of the Philadelphia-negative patient, the survival time of 27 months exceeded the median survival time usually reported for Philadelphia-negative CML patients, thus indicating a prognostic relevance of the missing Y chromosome.

Missing Y Chromosome in Ph1-Negative Chronic Myeloid Leukemia with bcr Rearrangement

“…The missing Y chromosome associated with Phi-negative CML has been reported quite rarely [4][5][6], although a significant proportion (6-8%) of CML patients show no Phi chromosome [11,12]. Re cently, great advances in investigating the molecular and biologic pathogenesis of CML have been made.…”

“…Although male patients with Philadelphia chromo some (Phl)-positive chronic myeloid leukemia (CML) sometimes show a loss of the Y chromosome [1][2][3], only a few cases of Phi-negative CML with missing Y chromosome as the sole abnormality have been reported [4][5][6]. These cases seem to be indis tinguishable clinically and hematologically from Phi-positive CML, but they show no evidence whether their molecular events are the same as those in Ph 1 -positive CML.…”