MISSION!: Optimization of acute and chronic care for patients with acute myocardial infarction

Liem, Su-San; Hoeven, Barend L. van der; Oemrawsingh, Pranobe V.; Bax, Jeroen J.; Bom, Johanna G. van der; Bosch, Jan; Viergever, Eric P.; Rees, C. van; Padmos, I.; Sedney, M. I.; Exel, Henk J. van; Verwey, Harriëtte F.; Atsma, Douwe E.; Velde, Enno T. van der; Jukema, J. Wouter; Wall, Ernst E. van der; Schalij, Martin J.

doi:10.1016/j.ahj.2006.10.002

Cited by 121 publications

(93 citation statements)

References 24 publications

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“…protocol in achieving predefined targets. 6 Furthermore, despite significant differences in transportation time (due to differences in distance from the PCI centre) similar time intervals between the onset of symptoms to arrival at the cath lab in all four areas of residence demonstrate that the multidisciplinary pre-hospital care is uniformly distributed and well organised in the region Hollands-Midden. Furthermore, even though physical distance was of influence on the time needed to get the patient to the hospital (from the start of symptoms), the short door-tocath lab time (median 23 min) levelled out these differences.…”

Section: Structured Care For Ami Patientsmentioning

confidence: 91%

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Standardised pre-hospital care of acute myocardial infarction patients: MISSION! guidelines applied in practice

Atary

Visser²,

Dijk³

et al. 2010

NHJL

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Despite significant regional differences in ambulance transportation times no difference in total time from onset of symptoms to arrival at the catheterisation room was found. Peak troponin T was 3.33 (IQR 1.23-7.04) mg/l, hospital stay was 2 (IQR 2-3) days and in-hospital mortality was 2.3%. Twelve percent had 0 known risk factors, 30% had one risk factor, 45% two to three risk factors and 13% had four or more risk factors. No significant differences were observed for AMI risk profiles and medication pre-AMI. Conclusions. This study shows that a standardised regional AMI treatment protocol achieved optimal and uniformly distributed pre-hospital performance in the region 'Hollands-Midden', resulting in minimal time delays regardless of area of residence. Hospital stay was short and in-hospital mortality low. Of the patients, 88% had ≥1 modifiable risk factor. (Neth Heart J 2010;18:408-15.)

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Section: Structured Care For Ami Patientsmentioning

confidence: 91%

“…was developed to optimise the use of evidence-based medicine in practice. 6 MIS-SION! contains a pre-hospital, in-hospital and outpatient clinical framework for decision-making and treatment of AMI patients.…”

mentioning

confidence: 99%

Standardised pre-hospital care of acute myocardial infarction patients: MISSION! guidelines applied in practice

Atary

Visser²,

Dijk³

et al. 2010

NHJL

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“…According to protocol, all patients were optimally treated with aspirin, clopidogrel, ␤-blockers, angiotensin-converting enzyme inhibitors, and statins, if tolerated. 12 …”

Section: Study Populationmentioning

confidence: 99%

“…12 The relation between several clinical and echocardiographic variables at baseline, particularly AFI global LV strain, and recovery of LV function at 1-year follow-up was evaluated. The study was approved by the institutional ethics committee, and informed consent was obtained from all patients.…”

Section: Patients and Study Protocolmentioning

confidence: 99%

Viability Assessment With Global Left Ventricular Longitudinal Strain Predicts Recovery of Left Ventricular Function After Acute Myocardial Infarction

Mollema

Delgado

Bertini

et al. 2010

Circ: Cardiovascular Imaging

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Background-The extent of viable myocardial tissue is recognized as a major determinant of recovery of left ventricular (LV) function after myocardial infarction. In the current study, the role of global LV strain assessed with novel automated function imaging (AFI) to predict functional recovery after acute infarction was evaluated. Methods and Results-A total of 147 patients (mean age, 61Ϯ11 years) admitted for acute myocardial infarction were included. All patients underwent 2D echocardiography within 48 hours of admission. Significant relations were observed between baseline AFI global LV strain and peak level of troponin T (rϭ0.64), peak level of creatine phosphokinase (rϭ0.62), wall motion score index (rϭ0.52), and viability index assessed with single-photon emission computed tomography (rϭ0.79). At 1-year follow-up, LV ejection fraction was reassessed. Patients with absolute improvement in LV ejection fraction Ն5% at 1-year follow-up (nϭ70; 48%) had a higher (more negative) baseline AFI global LV strain (PϽ0.0001). Baseline AFI global LV strain was a predictor for change in LV ejection fraction at 1-year follow-up. A cutoff value for baseline AFI global LV strain of Ϫ13.7% yielded a sensitivity of 86% and a specificity of 74% to predict LV functional recovery at 1-year follow-up. Conclusions-AFI global LV strain early after acute myocardial infarction reflects myocardial viability and predicts recovery of LV function at 1-year follow-up. (Circ Cardiovasc Imaging. 2010;3:15-23.)

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“…Therefore, several strategies have been developed to minimize the delay. In addition to inhospital and outpatient frameworks, educational programmes for timely medical care-seeking behaviour and prehospital protocols have been designed to improve outcomes [13][14][15][16]. Although the cause of prehospital delay in ACS is multifactorial and the duration from onset of symptoms until care-seeking is in part dependent on nonadjustable (patient) characteristics [17], some factors that cause delay in reperfusion after medical care-seeking are modifiable.…”

Section: Early Diagnosismentioning

confidence: 99%

Management of acute coronary syndrome: achievements and goals still to pursue. Novel developments in diagnosis and treatment

Boden

Hoeven

Karalis

et al. 2012

Journal of Internal Medicine

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. Boden H, van der Hoeven BL, Karalis I, Schalij MJ, Jukema JW (Leiden University Medical Center, Leiden, The Netherlands). Management of acute coronary syndrome: achievements and goals still to pursue. Novel developments in diagnosis and treatment (Review). J Intern Med 2012; 271: 521–536. Acute coronary syndromes contribute a substantial part of the global disease burden. To realize a reduction in mortality and morbidity, the management of patients with these conditions involves the integration of several different approaches. Timely delivery of appropriate care is a key factor, as the beneficial effect of reperfusion is greatest when performed as soon as possible. Innovations in antithrombotic therapy have also contributed significantly to improvements in the prevention of ischaemic complications. However, with the use of such treatment, an increase in the risk of bleeding is inevitable. Therefore, the greatest challenge is now to obtain an optimal balance between the prevention of ischaemic complications and the risk of bleeding. In this regard, identification of patients at highest risk of either one is essential.

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MISSION!: Optimization of acute and chronic care for patients with acute myocardial infarction

Cited by 121 publications

References 24 publications

Standardised pre-hospital care of acute myocardial infarction patients: MISSION! guidelines applied in practice

Standardised pre-hospital care of acute myocardial infarction patients: MISSION! guidelines applied in practice

Viability Assessment With Global Left Ventricular Longitudinal Strain Predicts Recovery of Left Ventricular Function After Acute Myocardial Infarction

Management of acute coronary syndrome: achievements and goals still to pursue. Novel developments in diagnosis and treatment

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