Mistletoe lectins: telomerase inhibitors in alternative cancer therapy

Li, Shi-Sheng

doi:10.1016/s1359-6446(02)02414-5

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…It should be noted that the gel maintained its robustness in the release media for over 1 week with almost no erosion or change in viscosity. These results are consistent with previously reported water‐soluble drug release from PLGA‐PEG‐PLGA thermoresponsive hydrogels …”

Section: Resultsmentioning

confidence: 99%

Effect of PLGA block molecular weight on gelling temperature of PLGA‐PEG‐PLGA thermoresponsive copolymers

Steinman

Haim-Zada

Goldstein

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Thermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l‐lactic acid‐co‐glycolic acid)‐b‐poly(ethylene glycol)‐b‐poly(d,l‐lactic acid‐co‐glycolic acid) (PLGA‐PEG‐PLGA) triblock copolymers exhibit a sol–gel transition upon heating. The effect of PLGA block and PEG chain molecular weights (MWs) on the gelling temperature of polymer aqueous solution (20% w/w) is described. All polymer solutions convert into a hard gel within 2 °C of the gelling temperature. The release properties of the gels were displayed using paracetamol as a representative drug. A linear relation is described between the gelling temperature and PLGA block MW. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 35–39

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Section: Resultsmentioning

confidence: 99%

Effect of PLGA block molecular weight on gelling temperature of PLGA‐PEG‐PLGA thermoresponsive copolymers

Steinman

Haim-Zada

Goldstein

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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“…The active CH2Cl2 soluble fraction (113 g) was chromatographed on the silica gel (12 × 75 cm, CH2Cl2：MeOH = 500：1 → 1：1) to give 14 fractions (Fr. [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Compound 1 (3 g) was obtained from Fr.…”

Section: Plant Material Extraction and Isolationmentioning

confidence: 99%

“…On the other hand, prothrombin time (PT) is measure of the extrinsic coagulation pathway (7,8). Mistletoe (Viscum album) is a semi-parasitic plant with a worldwide distribution in all over the world that grows on many kinds of trees, and its aqueous extracts have been used as anti-cancer agents for almost a century (9). Korean mistletoe (KM) is also used in traditional medicine to treat cancer, cardiovascular disease, and arthrosis (10), and studies of the biological effects of KM and of its chemical composition have demonstrated that the lectins of KM induce the apoptosis of cancer cells (11).…”

Section: Introductionmentioning

confidence: 99%

Anticoagulant activities of oleanolic acid via inhibition of tissue factor expressions

Lee

Yang²,

Ku³

et al. 2012

BMB Reports

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“…One explanation of the direct antineoplastic activity may be the inhibition of protein synthesis by the inactivation of ribosomes in tumor cells. The killing capacity of extracts from Viscum album L., widely used as an adjuvant in complementary cancer therapy, is dependent on the content of toxic proteins, especially the MLs (Li, 2002). Recombinant mistletoe lectin alone or in combination with ionizing radiation also showed down regulation of the proliferative activity and cell killing of transformed murine tumor cells in a clear dose response manner (0.1-1 ng/mL) (Hostanska et al, 2003).…”

Section: In Vitro Studiesmentioning

confidence: 99%

Lectins as Bioactive Plant Proteins: A Potential in Cancer Treatment

Mejı́a

Prisecaru

2005

Critical Reviews in Food Science and Nutrition

297

159

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Plant lectins, a unique group of proteins and glycoproteins with potent biological activity, occur in foods like wheat, corn, tomato, peanut, kidney bean, banana, pea, lentil, soybean, mushroom, rice, and potato. Thus, dietary intakes by humans can be significant. Many lectins resist digestion, survive gut passage, and bind to gastrointestinal cells and/or enter the circulation intact, maintaining full biological activity. Several lectins have been found to possess anticancer properties in vitro, in vivo, and in human case studies; they are used as therapeutic agents, preferentially binding to cancer cell membranes or their receptors, causing cytotoxicity, apoptosis, and inhibition of tumor growth. These compounds can become internalized into cells, causing cancer cell agglutination and/or aggregation. Ingestion of lectins also sequesters the available body pool of polyamines, thereby thwarting cancer cell growth. They also affect the immune system by altering the production of various interleukins, or by activating certain protein kinases. Lectins can bind to ribosomes and inhibit protein synthesis. They also modify the cell cycle by inducing non-apoptotic G1-phase accumulation mechanisms, G2/M phase cell cycle arrest and apoptosis, and can activate the caspase cascade. Lectins can also downregulate telomerase activity and inhibit angiogenesis. Although lectins seem to have great potential as anticancer agents, further research is still needed and should include a genomic and proteomic approach.

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Mistletoe lectins: telomerase inhibitors in alternative cancer therapy

Cited by 8 publications

References 8 publications

Effect of PLGA block molecular weight on gelling temperature of PLGA‐PEG‐PLGA thermoresponsive copolymers

Effect of PLGA block molecular weight on gelling temperature of PLGA‐PEG‐PLGA thermoresponsive copolymers

Anticoagulant activities of oleanolic acid via inhibition of tissue factor expressions

Lectins as Bioactive Plant Proteins: A Potential in Cancer Treatment

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