Misuse of Herbal Remedies: The Case of an Outbreak of Terminal Renal Failure in Belgium (Chinese Herbs Nephropathy)

Vanherweghem, Jean‐Louis

doi:10.1089/acm.1998.4.1-9

Cited by 209 publications

(129 citation statements)

References 17 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…accord with findings in human populations, where only a small fraction of AA-exposed individuals develop renal toxicity and/or urothelial cancer (4,23,24). The genetic basis for such relative susceptibility is yet to be determined.…”

Section: Discussionsupporting

confidence: 75%

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Chang¹,

et al. 2017

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 75%

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Chang¹,

et al. 2017

View full text Add to dashboard Cite

“…Vanherweghem (1998) described the occurrence of at least 100 cases of extensive interstitial fibrosis of the kidneys observed in Belgian women who had followed a weight loss program which included the use of Chinese herbs. Investigations following these cases suggested that (Han Fang Ji " ") was in fact mistakenly replaced with another Chinese herb Aristolochia fangchi (Guang Fang Ji " "), as evident from the absence of tetrandrine, a characteristic alkaloid in Stephania tetrandra, in the capsules taken by patients.…”

Section: Less-than-lifetime Exposurementioning

confidence: 99%

“…Investigations following these cases suggested that (Han Fang Ji " ") was in fact mistakenly replaced with another Chinese herb Aristolochia fangchi (Guang Fang Ji " "), as evident from the absence of tetrandrine, a characteristic alkaloid in Stephania tetrandra, in the capsules taken by patients. In addition, it was noted that the Chinese characters and pinyin name of the 2 herbs were similar with the exception of the prefix, and hence could have been easily confused for each other (Vanherweghem 1998). …”

Section: Less-than-lifetime Exposurementioning

confidence: 99%

The Regulatory Framework Across International Jurisdictions for Risks Associated with Consumption of Botanical Food Supplements

Low

Wong

Yap

et al. 2017

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Dietary supplements, including those containing botanical ingredients and botanical-derived compounds, have been marketed to consumers globally for many decades. However, the legislative framework for such products remains inconsistent across jurisdictions internationally. This study aims to compare the regulatory framework of botanical food supplements in the EU, USA, Canada, Australia, New Zealand, India, Japan, and China. The study also aims to investigate and describe safety assessment criteria for botanical food supplements where they are present in the above said jurisdictions, and attempts to analyze whether these criteria are suitable for addressing the toxicological risks associated with the use of botanical food supplement products, based on the evaluation of reported adverse effects related to botanical food supplement use as examples. Finally, this study discusses some future issues that need further attention, such as the consideration of less than lifetime exposures, potential for misidentification, and adulteration of botanical supplements by pharmacologically active substances. It is concluded that the regulatory approaches towards botanical food supplements differ significantly across jurisdictions. In addition, national authorities are increasingly considering having more regulatory oversight for such products. Further consideration of the actual impact of adverse events arising from botanical food supplement usage will be helpful in guiding such decisions.

show abstract

“…EN does not occur in children, but the inhabitants that have left the endemic area after over a decade of residence there are also known to develop EN. Patients with AAN usually developed the disease after several years of treatment with Chinese herbs (10,11). In some cases nephropathy was characterised by a rapid deterioration in renal function, with initial serum creatinine doubling within about three months.…”

Section: Epidemiological Features Of Endemic Nephropathy and Chinese mentioning

confidence: 99%

Mycotoxic and Aristolochic Acid Theories of the Development of Endemic Nephropathy

Peraica¹,

Domijan²,

Šarić³

2008

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Despite many efforts of scientists and epidemiologists, the aetiology of endemic nephropathy (EN) is still unknown. This disease occurs in the rural population of geographically limited areas of Bulgaria, Bosnia and Herzegovina, Croatia, Romania, and Serbia, and a number of theories have been proposed about its aetiology. The mycotoxin theory has prevailed until now, based on the studies of nephrotoxic mycotoxin ochratoxin A (OTA) that revealed higher frequency of OTA-positive food and blood samples in endemic than in non-endemic areas. However, a new aristolochic acid (AA) theory of EN origin has been proposed recently, due to the histological similarities in kidney lesions between patients suffering from EN and patients suffering from Chinese herbs nephropathy caused by AA. Until now it has not been unequivocally proved that the inhabitants of EN areas are exposed to higher concentration of AA than in other regions and the exposure pathways are rather uncertain. This paper presents most important studies supporting both theories, indicating also the inconsistencies of each.

show abstract

Misuse of Herbal Remedies: The Case of an Outbreak of Terminal Renal Failure in Belgium (Chinese Herbs Nephropathy)

Cited by 209 publications

References 17 publications

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

The Regulatory Framework Across International Jurisdictions for Risks Associated with Consumption of Botanical Food Supplements

Mycotoxic and Aristolochic Acid Theories of the Development of Endemic Nephropathy

Contact Info

Product

Resources

About