Mit klinischer Elektrophysiologie hinter die Netzhaut

Hoffmann, Michael B.; Heinrich, Sven; Thieme, Hagen; Al-Nosairy, Khaldoon O.

doi:10.1055/a-0715-8072

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Due to the complicated folding of V1, for some field locations, the corresponding activity in V1 does not sufficiently project to the scalp electrodes, even if multiple channels [ 53 ] are used. A detailed discussion is available here [ 24 ], and the conclusion by Graham [ 54 ] still holds “The mfVEP is particularly useful for investigating patients with field loss that does not match the clinical picture, either because they are poor performers on subjective tests or there is a suspicion of other pathology.” as exemplified in [ 55 ]. In conclusion, mfVEPs do not out-perform subjective perimetric tests in the detection of VF defect and consequently do not provide means for early detection of glaucoma.…”

Section: Mfvepmentioning

confidence: 99%

Non-invasive electrophysiology in glaucoma, structure and function—a review

Al-Nosairy

Hoffmann

Bach

2021

Eye

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Glaucoma, its early diagnosis, and monitoring of interventions remain an ongoing challenge. We here review developments in functional assessment and its relation to morphology, evaluating recent insights in electrophysiology in glaucoma and highlighting how glaucoma research and diagnostics benefit from combined approaches of OCT and electrophysiological investigations. After concise overviews of OCT and non-invasive electrophysiology in glaucoma, we evaluate commonalities and complementarities of OCT and electrophysiology for our understanding of glaucoma. As a specific topic, the dynamic range (floor effects) of the various techniques is discussed.

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Section: Mfvepmentioning

confidence: 99%

Non-invasive electrophysiology in glaucoma, structure and function—a review

Al-Nosairy

Hoffmann

Bach

2021

Eye

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“…The electroretinogram (ERG) is a decisive tool for the assessment of the functional integrity of the retina in clinical electrophysiology [1]. While conventional electrophysiology, such as the full-field ERG (ffERG), does not allow for a spatially resolved assessment, this can be provided by using multifocal stimulation techniques [2]. Sutter and Tran [3] introduced a multifocal technique of the ERG by utilizing pseudorandom binary m-sequences that enabled spatially resolved functional mapping of the retina, i.e., multifocal ERG (mfERG) [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Comparison of DTL and gold cup skin electrodes for recordings of the multifocal electroretinogram

2022

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Objective To compare mfERG recordings with the Dawson–Trick–Litzkow (DTL) and gold cup skin electrode in healthy young and old adults and to test the sensitivity of both electrodes to age-related changes in the responses. Methods Twenty participants aged 20–27 years (“young”) and 20 participants aged 60–75 (“old”) with a visual acuity of ≤ 0 logMAR were included. The mfERG responses were recorded simultaneously using DTL and skin electrodes. P1 amplitudes, peak times and signal-to-noise ratios (SNRs) were compared between both electrodes and across age groups, and correlation analyses were performed. The electrode’s performance in discriminating between age groups was assessed via area under curve (AUC) of receiver operating characteristics. Results Both electrodes reflected the typical waveform of mfERG recordings. For the skin electrode, however, P1 amplitudes were significantly reduced (p < 0.001; reduction by over 70%), P1 peak times were significantly shorter (p < 0.001; by approx. 1.5 ms), and SNRs were reduced [(p < 0.001; logSNR ± SEM DTL young (old) vs gold cup: 0.79 ± 0.13 (0.71 ± 0.15) vs 0.37 ± 0.15 (0.34 ± 0.13)]. All mfERG components showed strong significant correlations (R2 ≥ 0.253, p < 0.001) between both electrodes for all eccentricities. Both electrodes allowed for the identification of age-related P1 changes, i.e., P1-amplitude reduction and peak-time delay in the older group. There was a trend to higher AUC for the DTL electrode to delineate these differences between age groups, which, however, failed to reach statistical significance. Conclusions Both electrode types enable successful mfERG recordings. However, in compliant patients, the use of the DTL electrode appears preferable due to the larger amplitudes, higher signal-to-noise ratio and its better reflection of physiological changes, i.e., age effects. Nevertheless, skin electrodes appear a viable alternative for mfERG recordings in patients in whom the use of corneal electrodes is precluded, e.g., children and disabled patients.

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“…Wie gut der Patient sieht, lässt sich jedoch nicht direkt durch physiologische oder morphologische Untersuchungen feststellen. Obgleich es Ansätze zur Objektivierung gibt [1], etwa die Visusschätzung auf Basis visuell evozierter Potenziale (z. B.…”

Section: Introductionunclassified

Sehschärfe, Kontrastempfindlichkeit, Farbensehen: Gedanken zu psychophysischen Untersuchungen in der Neuroophthalmologie

Heinrich

Hoffmann

2018

Klin Monatsbl Augenheilkd

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ZusammenfassungTrotz aller technischen Fortschritte in der ophthalmologischen Diagnostik spielt die psychophysische Untersuchung der individuellen Sehleistungen weiterhin eine wichtige Rolle. Dies gilt insbesondere für neuroophthalmologische Fragestellungen. Der vorliegende Artikel betrachtet methodische und klinische Aspekte der Untersuchung von Sehschärfe, Kontrastempfindlichkeit und Farbsehvermögen. Im Gegensatz zur Sehschärfe wird die Kontrastempfindlichkeit bislang nur selten untersucht, obgleich ihre Reduktion in vielen Fällen ein sensitiverer Indikator einer Erkrankung ist. Generell haben standardisierte Verfahren, wie sie insbesondere für die Sehschärfeprüfung existieren, den Vorteil der Vergleichbarkeit. Vom Standard abweichende Verfahren können hierbei jedoch unter Umständen die spezifischen, für eine Erkrankung charakteristischen Sehstörungen besser erfassen, sodass deren Anwendung im konkreten Einzelfall gerechtfertigt ist. Dies zeichnet sich auch für die Testung des Farbensehens ab. Bisherige Studien deuten darauf hin, dass die Messung der Farbsättigungsschwelle bei erworbenen Farbsehstörungen eine effiziente und sensitive Alternative zu herkömmlichen Farbsehtests darstellen könnte.

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Mit klinischer Elektrophysiologie hinter die Netzhaut

Cited by 6 publications

References 44 publications

Non-invasive electrophysiology in glaucoma, structure and function—a review

Non-invasive electrophysiology in glaucoma, structure and function—a review

Comparison of DTL and gold cup skin electrodes for recordings of the multifocal electroretinogram

Sehschärfe, Kontrastempfindlichkeit, Farbensehen: Gedanken zu psychophysischen Untersuchungen in der Neuroophthalmologie

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