Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats

Ameliorative effect ofAegle marmelosleaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats

“…SOD brings about the conversion of highly toxic superoxide anion to hydrogen peroxide which is further detoxified by CAT. SOD is documented to get inactivated in diabetes by glycation while the superoxide anion causes inactivation of CAT which is the vital determinant of cardiac antioxidant status (Sefi et al, 2010). The decrease in the levels of TBARS and increase in the levels of GSH, SOD, and CAT indicates antioxidant activity of the plant.…”

Plant-Derived Agents with Anti-Glycation Activity

“…In 2010 Sefi et al demonstrated that administration of an aqueous extract of A. campestris to diabetic rats increased significantly serum insulin levels, reduced serum glucose level by 60% (p < 0.001) and tended to bring the glucose value to near normal after 21 days. The ability of A. campestris extracts to reduce the blood glucose level could be attributed to a stimulation of Plant-Derived Agents with Anti-Glycation Activity 235 langerhans islets, to an improvement of the peripheral sensitivity to remnant insulin, and to the strong antioxidant properties of the plant compounds [132].…”

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

“…Studies have also demonstrated hypoglycemic activities of flavonoids exerted by the prevention of oxidative stress in pancreatic β-cells [91][92]. In combination with anti-inflammatory capacities, these molecules may cause an improvement in blood glucose levels and side effects of the disease [93].…”