Mitigating effects of vildagliptin in experimental diabetes with metabolic syndrome

Suman, Rajesh Kumar; Mohanty, Ipseeta Ray; Maheshwari, Ujwala; Borde, Manjusha K.; Deshmukh, Y. A.

doi:10.18203/2319-2003.ijbcp20161568

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Rats were randomly allocated into five groups (six rats each) as follows: Group 1: this group received normal laboratory diet, tap water ad libitum and given saline daily during the time of experiment. Group 2: this group fed HFHFD for 12 weeks and given saline daily during the time of experiment. Group 3: this group fed HFHFD for 12 weeks and omega‐3 oil (260 mg/kg) for the last 4 weeks Group 4: this group fed HFHFD for 12 weeks and metformin (100 mg/kg) for the last 4 weeks Group 5: this group fed HFHFD for 12 weeks and l ‐carnitine (200 mg/kg) for the last 4 weeks …”

Section: Methodsmentioning

confidence: 99%

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Zayed

Ain-Shoka

Shazly

et al. 2018

J Biochem & Molecular Tox

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Background Frequent consumption of fructose and saturated fatty acids increase risk of metabolic syndrome (MS). Features of MS include insulin resistance, dyslipidemia, visceral obesity, and hypertension. The aim of this study was to investigate the role of omega‐3 and l‐carnitine in ameliorating features of MS. Methods MS was induced in rats by high‐fructose high‐fat fed diet for 8 weeks. They were randomly divided into five groups: normal control, MS control group treated with saline, MS groups given omega‐3 (260 mg/kg), l‐carnitine (200 mg/kg), or metformin (100 mg/kg) daily for 4 weeks. Body weight, relative organ weight, glucose, insulin, adiponectin, and lipid profiles were estimated. Also glucose transporter 4 (GLUT4) content and peroxisome proliferator‐activated receptor‐gamma (PPARγ) protein expressions were determined. Results Omega‐3 and l‐carnitine caused decrease in both MS‐induced increase in body weight and glucose similar to metformin. They reduced insulin level and resistance with increased adiponectin, and correction of MS‐induced hyperlipidemia. Drugs also increased GLUT4 and PPARγ protein expression compared with MS control group. Conclusion Omega‐3 and l‐carnitine improve features of MS via increased GLUT4 and PPARγ expression.

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Section: Methodsmentioning

confidence: 99%

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Zayed

Ain-Shoka

Shazly

et al. 2018

J Biochem & Molecular Tox

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“…Besides, it inhibited the absorption of glucose during in situ gut perfusion with glucose. The extract enhanced glucose transport and insulin action in 3T3-L1 adipocytes(3) Oral administration for 28 days decreased serum glucose, increased pancreatic insulin, plasma insulin, liver glycogen and total oxidant status in STZ induced diabetic rats [27]Berberidaceae Berberis aristata DC.Daruharidra (S), Daru haldi (H), Indian barberry (E), Kingod (L)Shrub (W)/roots and stemsBerberine [28](1) A decoction of roots or stem bark with water (5–10 mL) is taken twice a day for 1–2 weeks(2) A decoction of B. aristata root and Terminalia chebula fruits is taken orally in the morningAqueous ethanol root extract (250 mg/kg) lowered the blood glucose level in ALX induced diabetic rats. It also increased the glucokinase and glucose-6-phosphate dehydrogenase activities and decreased glucose-6-phosphatase activity in diabetic rats which play a critical role in glucose homeostasis [29] Sinopodophyllum hexandrum (Royle) T.S.Ying (Syn.…”

Section: Resultsmentioning

confidence: 99%

Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region (Uttarakhand) Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

Kumar

Aswal

Chauhan

et al. 2019

Nat. Prod. Bioprospect.

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The Himalayan region is the treasure house of natural wealth, particularly of medicinal and aromatic plants. These plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders, asthma, diabetes, snake bite, fever, pain, eye diseases, diarrhoea, indigestion, jaundice, burn, wound, liver disorder, CNS disorders and urinary tract infection. The indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern technologies. Therefore, it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human inhabitation. The present study aimed to explore the medicinal plants of Chakrata region (Jaunsar–Bawar Hills), Uttarakhand, India used in the folk medicine for the management of diabetes by Jaunsari Tribe. In a comprehensive field survey, the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal community. All the information about the medicinal plants of the study area was documented in a field book. Various tools have been used to collect the samples for identification purpose and the authentication of the plants was done with the help of taxonomists. The literature on these plants was also searched from online (PubMed and Scopus) as well as from some textbooks and Ayurvedic classical texts. The present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata region. The information gathered from the local community revealed that the plants are effective in diabetes and one can use most of them without consulting a practitioner or traditional healer. The literature revealed that most of the surveyed plants are already used in the preparation of various antidiabetic formulations such as Chandraprabha vati, Nishamalaki chunra, Amritamehari churna and Nisakathakadi kashayam along with various patent drugs which are frequently prescribed by the Ayurvedic practitioners in India. The present study explored the traditional as well as scientific knowledge on the antidiabetic plants used by the tribal community. The documented information on these plants can be further used by the scientific community to develop new drugs/formulations with the help of modern techniques.

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Mitigating effects of vildagliptin in experimental diabetes with metabolic syndrome

Cited by 2 publications

References 15 publications

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Improvement of insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats treated with omega‐3 fatty acid orl‐carnitine

Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region (Uttarakhand) Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

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