Mitigating potential and antioxidant properties of aqueous seed extract of Leea guineensis against dichlorovos-induced toxicity in Wistar rats

Ajiboye, Basiru Olaitan; S.O, Salawu; B, Okezie; Oyinloye, Babatunji Emmanuel; Ojo, Alaba Olumide; S.A, Onikanni; A.O, Oso; O.S, Asoso; T.O, Obafemi

doi:10.5897/jtehs2014.0312

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…The methanolic extract of Leea asiatica leaves produced hepatoprotective activity by lowering the level of serum SGOT, SGPT, ALP, total bilirubin, total cholesterol and triglyceride in acetaminophen-induced experimental model [ 36 ]. An in vivo study conducted by Ajiboye et al., (2014) stated that the aqueous seed extract of Leea guineensis showed hepatoprotective activity against DDVP-induced oxidative stress by altering the levels of increased lipid peroxidation and enhancing decreased activities of antioxidative enzymes such as catalase, superoxide dismutase, and glutathione peroxidase [ 43 ]. In another study, it was found that the methanolic extract of Leea macrophylla leaves partially improved the hepatic damage in CCl 4 -induced Wistar albino rats and prevented oxidative damage as well [ 86 ].…”

Section: Pharmacological Activitymentioning

confidence: 99%

“…Phenylethyl-rutinoside(41), Icariside D1(42), Hexenylrutinoside(43), Everlastoside C(44) These diglycosidic compounds were identified from methanolic extract of aerial parts of Leea asiatica[35] Bergenin(45), Citroside A(46) These compounds were identified from methanolic extract of aerial parts of Leea asiatica[35] (7S,8R)-9 0 -O-acetylcedrusin (47), (3S,4S)-4-chloro-3hydroxypiperidin-2-one (48) These compounds were isolated from the ethanolic extract of the aerial parts of Leea aequata [39] trans-N-p-coumaroyltyramine (49), N-transferuloyltyramine (50), Vanillic acid (51), Syringic acid (52),α-hydroxyacetovanillone (53), 3,4,5-trihydroxybenzoic acid ethyl ester (54), Isotachioside (55), (6S,9S)-roseoside C (56), Scopoletin (57), 5-hydroxymethylfurfural (58)These compounds were isolated from the ethanolic extract of the aerial parts of Leea aequata[39] Amino Acids, Mucilage's These compounds were identified from aqueous fraction of ethanolic extract of Leea macrophylla root tubers[49] F. Hossain et al Heliyon 7 (2021) e06222…”

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confidence: 99%

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Traditional uses and pharmacological activities of the genus leea and its phytochemicals: A review

Hossain

Mostofa

Alam

2021

Heliyon

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Plants have been used as traditional medicine (TM) since ancient times and TM remains an effective treatment option in the primary health care system in developing countries, including Bangladesh. There are several reasons to use plants as TM, which are cheaply and easily available and have a cultural heritage of their uses across generations. Leea, a genus of the Vitaceae family, possesses a large number of medicinal plants. In this review, the literature data on the traditional uses and pharmacological activities of Leea species and their phytochemicals are compiled. All the information was collected from the scientific databases. Results: Leea species are endemic that have opened a promising research field to identify new leads against different diseases. Leea contains approximately 70 species, which are widely distributed throughout the Northern and Eastern Australia, South and Southeast Asia and parts of Africa. The Leea plants are used traditionally in different ailments such as fever, diarrhea, dysentery, joint pain, rheumatism, diabetes, bone fracture, body ache, wound, sexual disorders, and so on. The majority of the Leea species are the medicinal plants, which have anticancer, cytotoxic, antimicrobial, antidiabetic, hepatoprotective, cardiovascular, and CNS activity. Moreover, phytochemicals such as flavonoids, glycosides, phenols, terpenoids, steroids, volatile oils, alkaloids, proteins, quinine derivatives, tannins, saponins, and many other organic compounds have been reported in the Leea species (Leea indica, Leea macrophylla, Leea asiatica, Leea aequata, Leea rubra and Leea guineensis). The presence of phytochemicals and the in vitro and in vivo biological activities reported of these plants support their use as TM. Though original research articles related to the Leea genus are available, supportive reviews on phytochemicals and pharmacological activities remain scarce. Conclusion: Leea species are used as TM in different ailments and have a real interest in their diverse pharmacological properties. Also, Leea species contain a remarkable number of bioactive compounds. This review has provided a comprehensive report on the plants of Leea genus to identify its therapeutic potential and future prospects for betterment research. However, chemical and biological investigations of several species of Leea genus remain unexplored. Therefore, further studies on these species are necessary, especially regarding pharmacological properties, isolation of the compounds and mechanism of action for the development of new drugs.

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Section: Pharmacological Activitymentioning

confidence: 99%

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confidence: 99%

Traditional uses and pharmacological activities of the genus leea and its phytochemicals: A review

Hossain

Mostofa

Alam

2021

Heliyon

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“…Leea guineensis commonly called Red tree vine is an evergreen shrub or small tree that belongs to the family Leeaceae. It is locally called alugbokita and usually propagated by seed or stem cutting; the seed germinates in 14-21 days at 70° F and can grow up to 20ft high; the plant is widely distributed in moist, intermediate temperate zones in tropical Africa including Cote d'Ivoire, Liberia, Sierra Leone, Ghana, Cameroon and Nigeria [18], [19]. The plant is reported to exhibits potential in-vivo anti-tumour and antioxidant activity [20]; while it's antiinflammatory activity was also demonstrated in experimental animals.…”

Section: Introductionmentioning

confidence: 99%

Phytominerals and Phytochemical Studies of Azadiracthta indica, Leea guineensis and Parkia biglobosa Leaves

et al. 2018

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Medicinal plants have great importance in African medicine and are also used as precursors in drug discovery. The medicinal value of plants lie in their bioactive constituents which usually allow them to fight against several diseases. Plant-based natural constituents can be derived from any part of the plant like bark, leaves, flowers, roots, fruits, seeds. The mineral and phytochemical analysis of the leaves of Azadirachta indica, Parkia biglobosa and Leea guineensis were investigated. The leaves were collected from the Herbal Garden, Forestry Research Institute of Nigeria, Jericho hills, Ibadan, Nigeria and identified at Forest Herbarium Ibadan. Oyo State. The leaves were air dried and milled to powder using a medium-sized milling machine and stored in an air-tight container until needed for analysis. Phytochemical screening/analysis and mineral analysis were determined using standard analytical methods. Phytochemicals like Alkaloids, Flavonoids, Tannins, Saponins, Anthraquinone, Cardiac glycoside were determined. while Minerals, such as Potassium, Sodium determined using flame photometer; Calcium, Phosphorus, Magnesium, Iron, Zinc, Manganese, and Copper were determined using Atomic Absorption Spectrophotometer. Results indicates that the bioactive contents of the leaves varied significantly (p<0.05) among the medicinal plants. The phytochemical analysis showed that the three medicinal plants contained alkaloid, saponins, tannins, flavonoids, polyphenols, cardiac glycoside and anthraquinone in varying quantities with the trend: A indica > P. biglobosa > L. guineensis; the macro elements showed similar trend as the phytochemicals while the micro elements followed the trend: P. biglobosa > L. guineensis > A indica. These results conceivably indicate that the three medicinal plant are good source of essential minerals and phyto-nutrients which possess strong pharmacological activities and provide scientific credence for its therapeutic usage.

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“…Volatile and flammable hydrocarbons are stored in unspeakable places which have often times resulted in terrible fire accidents that brought loss of lives and properties. No wonder that, frequently, there are mass casualty reports in the Nigerian mass media on carbon monoxide poisoning from electrical power generators (Ajiboye et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Mitigating the use of Electric Generators: An Operative Model of Distance and Greening Buffers

Akindele¹,

Adejumobi²

2016

GJSETR

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Against the background of the incessant electric power failure and the extensive use of electric power generator, the study investigates the use of electric power generators; so as to proffer ecologically sustainable mitigation strategies. The relative incidence of generator use was appraised. Residents coping mechanism as well as its efficacy were also assessed. Across the three recognizable residential densities of the city having 20 political wards, 50 urban blocks (10%) were sampled. A questionnaire was administered to 511 respondents using a multi stage approach. Noise dosimeter was used to measure the noise level. Air samplers were also used to assess the magnitude of air pollution across the sampled units. X 2 , T-test and one-way ANOVA were used to explain the variation in the incidence of generator use and to compare the average concentration of pollution with the WHO tolerable standards. A high level incidence of power outage (81%) was observed to have encouraged a high incidence (78.6%) of electric generator use with X 2 , T-test showing a significant difference in the noise levels comparing distance intervals to the generator at α=.05. Distance was observed to abate noise and air quality was better with greens at 1.916. The study thus recommends a distance and green buffer to mitigate the negative effects of electric power generator use.

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Mitigating potential and antioxidant properties of aqueous seed extract of Leea guineensis against dichlorovos-induced toxicity in Wistar rats

Abstract: This work was carried out to access the mitigating potential of Leea guineensis aqueous seed extract against dichlorovos (DDVP)-induced toxicity in

Cited by 5 publications

References 31 publications

Traditional uses and pharmacological activities of the genus leea and its phytochemicals: A review

Traditional uses and pharmacological activities of the genus leea and its phytochemicals: A review

Phytominerals and Phytochemical Studies of Azadiracthta indica, Leea guineensis and Parkia biglobosa Leaves

Mitigating the use of Electric Generators: An Operative Model of Distance and Greening Buffers

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