Mitigation in the toxicity of graphene oxide nanosheets towards Escherichia coli in the presence of humic acid

Zhang, Xuan; Sui, Minghao; Yan, Xin; Huang, Tiandi; Yuan, Zhen

doi:10.1039/c6em00256k

Cited by 9 publications

(4 citation statements)

References 48 publications

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“…As for the graphene oxide, Zucker et al reported that the extent of membrane damage depended on the total surface area of graphene oxide (Zucker et al 2017). Normally, an eco-corona could hinder the physical contact between graphene and cell membranes through steric hindrance or electrostatic repulsion, which could reduce membrane damage (Zhang et al 2016;Zhao et al 2019). For invertebrate animals or zebrafish larvae, a few studies reported that HA could significantly increase the toxicity of graphene to organisms by enhancing its stability (Castro et al 2018;Clemente et al 2017).…”

Section: Mechanisms By Which Nom Influences the Toxicity Of Nms By Aq...mentioning

confidence: 99%

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

et al. 2022

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Nanomaterials (NMs) are able to interact with natural organic matter (NOM) such that NOM is adsorbed on the surface of NMs to form an ecological corona (eco-corona). The formation of an eco-corona can greatly influence the behavior, risk and fate of NMs in the environment. A systematic understanding of the impacts of an eco-corona on the hazards of NMs is crucial for NMs risk assessment in the aquatic environment. Herein, the mechanisms of the formation of an eco-corona were reviewed based on the representative literatures and their generality was discussed on the basis of the type of NMs, the type of NOM and the environmental conditions. The effects of an eco-corona on the bioaccumulation and toxicity of NMs for aquatic organisms were systematically discussed through reported studies. The results showed that an eco-corona could alter the toxicity of NMs by changing the dissolution of NMs, adhesion of NMs and the damages to bio-membranes, internalization, and the generation of NMs-induced reactive oxygen species. The dual effects of an eco-corona on the toxicity/accumulation of NMs were widely present because of the complex molecular composition of NOM, the diverse types of NMs, and the variable environmental conditions. The effects of an eco-corona on the fate and the effects of other pollutants (such as metals and organic pollutants) were also carefully reviewed. The results showed that more research is needed to investigate the effect of an eco-corona through the development of novel techniques, mathematical modeling, and mesocosm studies. Graphical Abstract

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Section: Mechanisms By Which Nom Influences the Toxicity Of Nms By Aq...mentioning

confidence: 99%

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

et al. 2022

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“…Humic acid (HA), the main existing form of NOMs (natural organic matters), can interact extensively with various engineered nanoparticles to improve their stability in aqueous solutions (Pradhan et al 2018). The potential contamination of a river or lake by NM can be mitigated by an abundancy of HA (Kteeba et al 2017) since it contains many hydrophilic groups that show excellent ability to adjust the behaviors and toxicities of NM in the environment (Zhang et al 2016). Indeed, some studies have shown that the presence of HA in the exposure medium alters the toxicity of the NMs (Dasari and Hwang 2013;Deng et al 2016;Hu et al 2011;Kim et al 2013;Yang et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Exploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish

Clemente

Silva

Nunes

et al. 2019

Environ Sci Pollut Res

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The presence of natural organic matter such as humic acid (HA) can influence the behavior of graphene oxide (GO) in the aquatic environment. In this study, zebrafish embryos were analyzed after 5 and 7 days of exposure to GO (100 mg L −1 ) and HA (20 mg L −1 ) alone or together. The results indicated that, regardless of the presence of HA, larvae exposed to GO for 5 days showed an increase in locomotor activity, reduction in the yolk sac size, and total length and inhibition of AChE activity, but there was no difference in enzyme expression. The statistical analysis indicated that the reductions in total larval length, yolk sac size, and AChE activity in larvae exposed to GO persisted in relation to the control group, but there was a recovery of these parameters in groups also exposed to HA. Larvae exposed to GO for 7 days did not show significant differences in locomotor activity, but the RT-PCR gene expression analysis evidenced an increase in the AChE expression. Since the embryos exposed to GO showed a reduction in overall length, they were submitted to confocal microscopy and their muscle tissue configuration investigated. No changes were observed in the muscle tissue. The results indicated that HA is associated with the toxicity risk modulation by GO and that some compensatory homeostasis mechanisms may be involved in the developmental effects observed in zebrafish.

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“…Humic acid as a natural organic matter has been found to be an effective graphene oxide toxicity alleviation agent in E. coli aqueous bacterial model. This natural agent exhibited an antioxidant action role, maintaining the activity of the antioxidant enzymes and decreasing the reactive oxygen species generation, as witnessed by the results of oxidative stress experiments, thereby having important ecotoxicology implications [120].…”

Section: Other Exploitable Environmental and Biological Factorsmentioning

confidence: 95%

Graphene toxicity as a double-edged sword of risks and exploitable opportunities: a critical analysis of the most recent trends and developments

Volkov

McIntyre²,

Prina-Mello

2017

2D Mater.

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Increased production volumes and a broadening application spectrum of graphene have raised concerns about its potential adverse effects on human health. Numerous reports demonstrate that graphene irrespective of its particular form exerts its effects on a widest range of living organisms, including prokaryotic bacteria and viruses, plants, micro-and macro-invertebrates, mammalian and human cells and whole animals in vivo. However, the available experimental data is frequently a matter of significant divergence and even controversy. Therefore, we provide here a critical analysis of the most recent (2015-2016) reports accumulated in the graphene-related materials biocompatibility and toxicology field in order to elucidate the cutting edge achievements, emerging trends and future opportunities in the area. Experimental findings from the diverse in vitro and in vivo model systems are analysed in the context of the most likely graphene exposure scenarios, such as respiratory inhalation, ingestion route, parenteral administration and topical exposure through the skin. Key factors influencing the toxicity of graphene and its complex derivatives as well as potential risk mitigation approaches exploiting graphene physicochemical properties, surface modifications and possible degradation pathways are also discussed along with its emerging applications for healthcare, diagnostics and innovative therapeutic approaches.

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Mitigation in the toxicity of graphene oxide nanosheets towards Escherichia coli in the presence of humic acid

Cited by 9 publications

References 48 publications

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

Exploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish

Graphene toxicity as a double-edged sword of risks and exploitable opportunities: a critical analysis of the most recent trends and developments

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