Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters)

Maiti, Sampa; Manna, Saikat; Shen, Jingjing; Esser‐Kahn, Aaron P.; Du, Wenjun

doi:10.1021/jacs.8b12205

Cited by 19 publications

(19 citation statements)

References 34 publications

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“…The hydrophobic part of NPs determines the immune response. Also, cytotoxicity is associated with the degree of hydrophobic substitution of NPs [18]. Therefore, the hydrophobic substitution degree in constructing drug carrier NPs should be carefully controlled, and the important properties and functional changes of NPs caused by different hydrophobic substitutions need investigation.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity

Yuan

Zhong

Wang

et al. 2020

Journal of Nanomaterials

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The formation of nanoparticles (NPs) and surface properties such as size and charge are affected by the amphiphilic property of polymer, which is vital for evaluating their function. Here, we synthesized cholesteryl-modified aminated pullulan polymers (CHPNs) with different amounts of cholesterol succinate (CHS). We characterized the three hydrophobically modified polymers (CHPN1, CHPN2, and CHPN3) (CHS: Pu‐NH2=1/5,2/5,3/5) by Fourier transform infrared spectrometry. Dynamic light scattering (DLS) was used to measure particle size and zeta potential of CHPN NPs. The particle sizes of the three NPs CHPN1, CHPN2, and CHPN3 were 178.0, 144.4, and 97.8 nm, respectively. The particle size was related to the cholesteryl substitution of polymers to a certain extent: the stronger the hydrophobicity, the smaller the particle size. In 48 h, the drug release for CHPN3 and CHPN1 NPs was 57.8% and 72.7%. Thus, the NPs showed good sustained drug release: the greater the degree of hydrophobic substitution, the better the sustained release. The cytotoxicity findings were reversed: CHPN1 NPs, with low hydrophobic substitution, showed the best inhibition of Lewis lung cancer cells.

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Section: Introductionmentioning

confidence: 99%

Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity

Yuan

Zhong

Wang

et al. 2020

Journal of Nanomaterials

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“…However, hydrophobic materials can be "masked" to prevent removal and reduce intrinsic immune activation by coating them with a hydrophilic material such as polyethylene glycol (PEG), for example. Such a strategy is useful to improve the delivery of vaccines with hydrophobic compounds in the particle core (Maiti et al, 2019). Nevertheless, surface modification of particles additionally modulates their half-life and distribution profile in the body.…”

Section: Charge Hydrophobicity and Other Chemical Propertiesmentioning

confidence: 99%

Engineering Targeting Materials for Therapeutic Cancer Vaccines

Briquez

Hauert

Titta³

et al. 2020

Front. Bioeng. Biotechnol.

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Therapeutic cancer vaccines constitute a valuable tool to educate the immune system to fight tumors and prevent cancer relapse. Nevertheless, the number of cancer vaccines in the clinic remains very limited to date, highlighting the need for further technology development. Recently, cancer vaccines have been improved by the use of materials, which can strongly enhance their intrinsic properties and biodistribution profile. Moreover, vaccine efficacy and safety can be substantially modulated through selection of the site at which they are delivered, which fosters the engineering of materials capable of targeting cancer vaccines to specific relevant sites, such as within the tumor or within lymphoid organs, to further optimize their immunotherapeutic effects. In this review, we aim to give the reader an overview of principles and current strategies to engineer therapeutic cancer vaccines, with a particular focus on the use of sitespecific targeting materials. We will first recall the goal of therapeutic cancer vaccination and the type of immune responses sought upon vaccination, before detailing key components of cancer vaccines. We will then present how materials can be engineered to enhance the vaccine's pharmacokinetic and pharmacodynamic properties. Finally, we will discuss the rationale for site-specific targeting of cancer vaccines and provide examples of current targeting technologies.

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“…With the advancement in new bioprocesses that use cellulose/lignocellulose as the feedstock; the price is expected to decrease further, and there are hopes that one day this class of polymer may potentially replace certain polymers arising from petroleum. Indeed, there is an increasing number of studies on the synthesis of glucose‐based polymers, as a few of these examples shown in Figure , including sugar polyamide ( IIIa ), sugar polycarbonate ( IIIb ) and sugar poly(orthoester) ( IIIc ) . However, in all of these studies, glucose must be first converted into a polymerizable monomer, often, in a stepwise manner, and requiring chromatographic purification in each step.…”

Section: Figurementioning

confidence: 99%

From Glucose to Polymers: A Continuous Chemoenzymatic Process

et al. 2020

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Efforts to synthesize degradable polymers from renewable resources are deterred by technical and economic challenges; especially, the conversion of natural building blocks into polymerizable monomers is inefficient, requiring multistep synthesis and chromatographic purification. Herein we report a chemoenzymatic process to address these challenges. An enzymatic reaction system was designed that allows for regioselective functional group transformation, efficiently converting glucose into a polymerizable monomer in quantitative yield, thus removing the need for chromatographic purification. With this key success, we further designed a continuous, three‐step process, which enabled the synthesis of a sugar polymer, sugar poly(orthoester), directly from glucose in high yield (73 % from glucose). This work may provide a proof‐of‐concept in developing technically and economically viable approaches to address the many issues associated with current petroleum‐based polymers.

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Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters)

Abstract: Polymeric nanoparticles (NPs) derived from self-assemblies of amphiphilic polymers have demonstrated great potential in clinical applications.

Cited by 19 publications

References 34 publications

Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity

Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity

Engineering Targeting Materials for Therapeutic Cancer Vaccines

From Glucose to Polymers: A Continuous Chemoenzymatic Process

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