“…Due to the variation in the mechanisms involved in the organisms when they are exposed to the pollutant, results interpretation from a combination of the biomarkers has more advantage than interpreting single biomarker results. As results interpretation from multi-biomarker could provide the overall impact of a specific pollutant (i.e., STX), the integrated biomarker responses (IBRs), as an indicator of environment stress, has been widely used in stress responses and ecological risk assessment of marine pollutants including toxins ( Beliaeff and Burgeot, 2002 ; Wang et al, 2011 , 2018 ; Pain-Devin et al, 2014 ; Yan et al, 2014 ; Martínez-Ruiz and Martínez-Jerónimo, 2015 , 2017 ; Nogueira et al, 2015 ; Meng et al, 2016 ; Teles et al, 2016 ; Vieira et al, 2016 ; Devin et al, 2017 ; Duarte et al, 2017 ; Li et al, 2017 ; Luna-Acosta et al, 2017 ; Sanchez-García et al, 2017 ; Sobjak et al, 2017 ; Valerio-García et al, 2017 ). In addition, the integrated approach combining conventional toxicological bioassays with predictive biomarkers in native mussels might represent an additional tool for Control Agencies and Administrators dealing with management of human risk and economical damage caused by STX secreted by harmful algal blooms ( Beliaeff and Burgeot, 2002 ).…”