“…For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org effects of intradermal injection of normal saline with benzyl alcohol or lidocaine in 40, 47, and 221 preoperative adults, respectively. Other researchers investigated alternative methods of analgesia for IV insertions, including topical skin coolants (Hartstein & Barry, 2008), a topical local anesthetic cream (Luhmann, Hurt, Shootman, & Kennedy, 2004) or patch (Sethna et al, 2005), and selfselected music therapy (Jacobsen, 1999), all with positive results. Svensson, Rosen, and Nilsson (2006) randomized 125 ambulatory patients to receive either local warming for one minute or no treatment prior to IV insertion and found that local warming did not have any pain-reducing effect.…”