Mitigative impact of bradykinin potentiating factor isolated from <i>Androctonus amoreuxi</i> scorpion venom and low doses of γ-irradiation on doxorubicin induced hepatotoxicity through ang II/AMPK crosstalk

Hasan, Hesham Farouk; Galal, Shereen Mohamed; Ellethy, Rania A.

doi:10.1080/15376516.2022.2049941

Cited by 2 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The enzyme-linked immunosorbent assay (ELISA) kits of hormone-sensitive lipase (HSL) and Adipose triglyceride lipase (ATGL) were obtained from Huamei Bioengineering Co, Ltd. All other regents and chemicals were obtained from local agencies. [13,14] and our previous studies. [15,16] The same amount of 0.9% saline was given to the control group.…”

Section: Drugs and Chemicalssupporting

confidence: 68%

See 1 more Smart Citation

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Wang

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Doxorubicin (DOX), is a high efficiency anthracycline antitumor drug. However, the clinical application of DOX is limited mainly by dose-related adverse drug reactions.Currently, the therapeutic effects of Atorvastatin (ATO) on DOX-induced hepatotoxicity were studied in vivo. The results indicated that DOX impaired hepatic function, as measured by an increased levels of liver weight index and serum concentrations of aspartate transaminase and alanine transaminase, as well as alteration of hepatic histology. In addition, DOX increased the serum levles of triglyceride (TG) and nonestesterified fatty acid. ATO prevented these changes.Mechanical analysis revealed that ATO restored the changes of malondialdehyde, reactive oxygen radical species, glutathione peroxidase and manganese superoxide dismutase. Additionally, ATO inhibited the increased expression levels of nuclear factor-kappa B and interleukin 1β, hence suppressing inflammation. Meanwhile, ATO inhibited cell apoptosis by dramatically decreasing the Bax/Bcl-2 ratio. In addition, ATO mitigated the lipidtoxicity by inhibiting the adipolysis of TG and accelerating hepatic lipid metabolism. Taken together, the results suggest ATO has therapeutic effect on DOX-induced hepatotoxicity via inhibition of oxidative damage, inflammatory and apoptosis. In addition, ATO attenuates DOX-induced hyperlipidemia via modulation of lipid metabolism.

show abstract

Section: Drugs and Chemicalssupporting

confidence: 68%

“…The animal received an intraperitoneal dose of DOX 10 mg/kg in a dose volume of 1 mL/100 g body weight. The dosage of DOX was determined based on literature [ 13,14 ] and our previous studies. [ 15,16 ] The same amount of 0.9% saline was given to the control group.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Wang

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

Scorpion Venom Peptides as Therapeutic Agents in Cardiovascular Diseases: A Systematic Review

Santos,

Silva,

de Matos

2024

Int J Pept Res Ther

View full text Add to dashboard Cite

Mitigative impact of bradykinin potentiating factor isolated from Androctonus amoreuxi scorpion venom and low doses of γ-irradiation on doxorubicin induced hepatotoxicity through ang II/AMPK crosstalk

Cited by 2 publications

References 53 publications

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Scorpion Venom Peptides as Therapeutic Agents in Cardiovascular Diseases: A Systematic Review

Contact Info

Product

Resources

About