2020
DOI: 10.1016/j.biomaterials.2019.119668
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Mitochondria-acting nanomicelles for destruction of cancer cells via excessive mitophagy/autophagy-driven lethal energy depletion and phototherapy

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Cited by 86 publications
(58 citation statements)
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“…Polyethylene glycol (PEG) 1000 vitamin E succinate (TPGS) is a P-gp inhibitor. The structure of TPGS includes a vitamin E succinate (α-TOS) and a hydroxyl ester of PEG 1000, which can inhibit the function of P-gp ATPase, disrupt mitochondrial membrane potential, and reduce intracellular ATP levels [ 9 , 10 ]. For these reasons, TPGS can overcome tumor MDR and increase drug accumulation within cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…Polyethylene glycol (PEG) 1000 vitamin E succinate (TPGS) is a P-gp inhibitor. The structure of TPGS includes a vitamin E succinate (α-TOS) and a hydroxyl ester of PEG 1000, which can inhibit the function of P-gp ATPase, disrupt mitochondrial membrane potential, and reduce intracellular ATP levels [ 9 , 10 ]. For these reasons, TPGS can overcome tumor MDR and increase drug accumulation within cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…Overall, excessive, or impaired mitophagy/autophagy appears to trigger the AACD routine. The boosted mitophagy activation mediated by TPGS/dc-IR825-PDT exceeds the degradative function of autolysosomes, ending up with huge vacuolization and degradation impairment, as well as depletion of ATP, activation of AMPK pathway, and bioenergetic catastrophe (141). Such effects were also observed in xenografts models when TPGS/dc-IR825 nanomicelles were intravenously injected into tumor-bearing mice showing high tumor accumulation and retention (141).…”
Section: The Pro-death Autophagy Rolementioning
confidence: 95%
“…Some reports have shown that depending on the stress level, the autophagic apparatus might intrinsically contribute to other cell death programs, like apoptosis or necroptosis (35,56,59,62,104,128,141,144,145,147,155,(166)(167)(168)(169)(170), see Table 2. In spite of not inducing cell death per si, the RCD routine autophagymediated cell death (AMCD) may be significantly rescued by chemical autophagic inhibition (e.g.…”
Section: The Pro-death Autophagy Rolementioning
confidence: 99%
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“…It has been reported that some cyanine-based molecules or composite materials possess a strong near-infrared (NIR) absorption character and can realize not only phototherapy but also NIR fluorescence imaging under a single wavelength excitation. Cyanine-based agents mainly include heptamethine cyanine-based agents like indocyanine green [33][34][35][36][37][38][39][40][41][42], phthalocyanine-based agents [43][44][45][46], and others [47,48]. IR825, a heptamethine cyanine dye, shows high photothermal conversion efficiency, good biodegradability, mitochondria-targeting property, and fluorescence imaging capability, which are beneficial for cancer theranostics [49,50].…”
Section: Introductionmentioning
confidence: 99%