Mitochondria and Cell Death

Aken, Olivier Van

doi:10.1002/9781119312994.apr0553

Cited by 4 publications

(3 citation statements)

References 179 publications

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“…Intrinsic apoptosis is activated from within the cell in response to injury or other forms of stress, such as DNA damage, lack of oxygen, UV radiation, nutrient or survival signals, oxidizing agents, drugs, and growth factors 49 (Fig. 4).…”

Section: Intrinsic Pathway: Mitochondrial Death Pathwaymentioning

confidence: 99%

Untitled

2024

Investigación Clínica

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Section: Intrinsic Pathway: Mitochondrial Death Pathwaymentioning

confidence: 99%

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2024

Investigación Clínica

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Section: Intrinsic Pathway: Mitochondrial Death Pathwaymentioning

confidence: 99%

Mechanisms of programmed cell death: structural and functional pathways. A narrative review.

Fernández-Lázaro,

Sanz,

Seco-Calvo

2024

Investigación Clínica

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Apoptosis, necroptosis, and autophagy are cellular mechanisms by which cells are programmed to die under various physiological and devel-opmental stimuli. A multitude of protein mediators of programmed cell death have been identified, and apoptosis, necroptosis, and autophagy signals have been found to utilize common pathways that elucidate the proteins involved. This narrative review focuses on caspase-dependent and caspase-independent programmed cell death systems. Including studies of caspase-dependent pro-grammed cell death, extrinsic pathway apoptotic mechanisms, phosphatidyl-serine (PS), FAS (APO-1/CD95), tumor necrosis factor (TNF) receptor type 1 (TNF-R1) and TNF-related apoptosis-inducing ligand (TRAIL), and intrinsic or mitochondrial pathway such as cytochrome C, the Bcl-2 family of proteins and Smac/Diablo. The Bcl-2 family has apoptotic mediators Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak), Bcl-2-interacting protein BIM (Bim), Bcl-2 agonist of cell death (Bad), Bid, Bcl-2 adenovirus E1B 19kDa-interacting protein 1 NIP3 (Bnip3), BMF, HRK, Noxa and PUMA and an-tiapoptotic proteins such as Bcl-2 itself, Mcl-1, Bcl-w, A1, and Bcl-XL. Moreover, caspase-independent programmed cell death pathways include the mitochon-drial pathway with the protein mediators apoptosis inducing factor (AIF) and endonuclease G, and the pathways necroptosis, and autophagy. Understanding programmed cell death from those reported in this review could shed substantial light on the processes of biological homeostasis. In addition, identifying specific proteins involved in these processes is mandatory to identify molecular biomarkers and therapeutic targets. Furthermore, it could provide the ability to modulate the programmed cell death response and could lead to new therapeu-tic interventions in a disease.

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“…Plant mitochondria have additional roles in stress responses, including abiotic stress tolerance and the orchestration of programmed cell death (Aken, 2018;Scott & Logan, 2008;Suzuki et al, 2012),in cellular redox regulation and the management of reactive oxygen species (ROS) (Geigenberger & Fernie, 2014), and in the biosynthesis of key metabolites such as amino acids, fatty acids, vitamin co-factors or tetrapyrroles (Fernie et al, 2020;Mackenzie & McIntosh, 1999;Palmer, 1979).…”

Section: Introductionmentioning

confidence: 99%

Inactivation of mitochondrial complex IV inPhyscomitrium patensreveals the essential role of respiration in coordinating plants metabolism

Vera-Vives,

Mellon,

Gurrieri

et al. 2024

Preprint

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Photosynthetic organisms use sunlight as energy source but rely on respiration during the night and in non-photosynthetic tissues. Respiration is also active in photosynthetically active cells, where its role is still unclear due to a lack of viable mutants. Plants lacking cytochrome c oxidase (complex IV) activity are generally lethal but were here isolated exploiting the possibility of generating knockout lines through vegetative propagation in the moss Physcomitrium patens. The mutants showed severely impaired growth, with an altered composition of the respiratory apparatus and increased electron transfer through the alternative oxidase. The light phase of photosynthesis remained largely unaffected while the efficiency of carbon fixation was moderately reduced. Transcriptomic and metabolomic analyses showed that the disruption of the cytochrome pathway had broad consequences for carbon and nitrogen metabolism. A major alteration in nitrogen assimilation was observed with a general reduction in amino acid abundance. A partial rescue of the growth could be obtained by growing the plants with an external supply of amino acids but not with sugars, demonstrating that respiration in plant photosynthetic cells plays an essential role at the interface between carbon and nitrogen metabolism and a key role in providing carbon skeletons for amino acid biosynthesis.

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Mitochondria and Cell Death

Cited by 4 publications

References 179 publications

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Mechanisms of programmed cell death: structural and functional pathways. A narrative review.

Inactivation of mitochondrial complex IV inPhyscomitrium patensreveals the essential role of respiration in coordinating plants metabolism

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