Mitochondria and Their Role in Human Reproduction

Zou, Weiwei; Slone, Jesse; Cao, Yunxia; Huang, Taosheng

doi:10.1089/dna.2019.4807

Cited by 14 publications

(4 citation statements)

References 66 publications

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“…The sperm contributes half of the genetic material to the embryo but, after fertilization, its mitochondria are frequently destroyed or damaged. Studies demonstrating that errors in mitochondrial activity can result in a variety of reproductive pathologies, including infertility, miscarriage, and developmental abnormalities, have raised awareness of the significance of mitochondrial function in human reproduction [40].…”

Section: Discussionmentioning

confidence: 99%

The Ratio of cf-mtDNA vs. cf-nDNA in the Follicular Fluid of Women Undergoing IVF Is Positively Correlated with Age

Tsirka,

Zikopoulos,

Papageorgiou

et al. 2023

Genes

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Age-related mitochondrial markers may facilitate the prognosis of artificial reproductive technology outcomes. In this report, we present our study concerning the ratio of cf-mtDNA/cf-nDNA, namely the amount of cell-free mitochondrial DNA relative to cell-free nuclear DNA, in the follicular fluid (FF) of women undergoing IVF, aiming to generate a molecular fingerprint of oocyte quality. The values of this ratio were measured and compared among three groups of women (101 in total): (A) 31 women with polycystic ovary syndrome (PCOS), (B) 34 women younger than 36 years, and (C) 36 women older than 35 years of age. Real-time quantitative PCR (qPCR) was performed to quantify the ratio by using nuclear- and mitochondrial-specific primers and analyzed for potential correlation with age and pregnancy rate. Our analysis showed that the level of FF-cf-mtDNA was lower in the group of advanced-age women than in the groups of PCOS and non-PCOS women. Moreover, a significant positive correlation between FF-cf-mtDNA and the number of mature (MII) oocytes was observed. Collectively, the data show that the relative ratio of cf- mtDNA to cf-nDNA content in human FF can be an effective predictor for assessing the corresponding oocyte’s age-related performance in IVF.

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Section: Discussionmentioning

confidence: 99%

The Ratio of cf-mtDNA vs. cf-nDNA in the Follicular Fluid of Women Undergoing IVF Is Positively Correlated with Age

Tsirka,

Zikopoulos,

Papageorgiou

et al. 2023

Genes

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“…A well-established improvement in sexual hormones, insulin resistance, and weight loss in obese women with PCOS following this diet has been reported in several publications, which might be the reason why fertility in these women is enhanced [ 61 , 62 , 63 ]. Moreover, mitochondrial function also appears to be enhanced in this type of diet, which is closely linked with reproduction function [ 64 , 65 ].…”

Section: Dietsmentioning

confidence: 99%

Do Popular Diets Impact Fertility?

Salvaleda-Mateu,

Rodríguez-Varela,

Labarta

2024

Nutrients

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Infertility affects 15% of the population in developed countries, and its prevalence is increasing. Fertility can be influenced by different factors. Although key factors like maternal age cannot be changed, there is growing evidence that other modifiable factors, such as diet, can have an impact on fertility. Diet has become increasingly important in recent years for a number of reasons: the new trend toward a healthy lifestyle, the higher prevalence of certain digestive disorders, a lack of time that leads people to consume more prepared and processed food, and personal choice to not eat meat, among others. To meet these needs, several diets have recently become popular, such as the Mediterranean diet, known as the gold standard of health; the DASH diet, known for preventing hypertension; the Western diet, characterized by processed food; the ketogenic diet, characterized by low carbohydrate intake; and the vegetarian diet, which is the choice for people who do not eat meat or animal by-products. Diets present a unique composition characterized by the presence or absence of specific nutrients, which have also been associated with male and female fertility individually. This review assesses the impact of these diets and of macro- and micronutrients on both female and male fertility.

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“…The most promising method of oocyte renewing taking in to consideration mitochondrial free radical theory of aging is mitochondrial replacement therapy (MRT). As known that, unlike the nuclear genome, which is inherited equally from both parents, the mitochondrial genome is transmitted mainly from the mothers' gamete (Zou et al, 2020). Mitochondrial DNA is circular in structure and contains 37 genes controlling production of proteins involved in energy metabolism.…”

Section: Womanmentioning

confidence: 99%

State of the art in assisted reproductive technologies for patients with advanced maternal age

Yurchuk

Petrushkо

Fuller

2023

Zygote

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Summary According to the World Health Organization, the female reproductive age lasts up to 49 years, but problems with the realization of women’s reproductive rights may arise much earlier. Significant numbers of factors affect the state of reproductive health: socioeconomic, ecological, lifestyle features, the level of medical literacy, and the state of the organization and medical care quality. Among the reasons for fertility decline in advanced reproductive age are the loss of cellular receptors for gonadotropins, an increase in the threshold of sensitivity of the hypothalamic-pituitary system to the action of hormones and their metabolites, and many others. Furthermore, negative changes accumulate in the oocyte genome, reducing the possibility of fertilization, normal development and implantation of the embryo and healthy offspring birth. Another theory of ageing causing changes in oocytes is the mitochondrial free radical theory of ageing. Taking into account all these age-related changes in gametogenesis, this review considers modern technologies aimed at the preservation and realization of female fertility. Among the existing approaches, two main ones can be distinguished: methods allowing the preservation of reproductive cells at a younger age using ART intervention and cryobanking, as well as methods aimed at improving the basic functional state of advanced-age women’s oocytes and embryos.

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Mitochondria and Their Role in Human Reproduction

Cited by 14 publications

References 66 publications

The Ratio of cf-mtDNA vs. cf-nDNA in the Follicular Fluid of Women Undergoing IVF Is Positively Correlated with Age

The Ratio of cf-mtDNA vs. cf-nDNA in the Follicular Fluid of Women Undergoing IVF Is Positively Correlated with Age

Do Popular Diets Impact Fertility?

State of the art in assisted reproductive technologies for patients with advanced maternal age

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