Mitochondria: how eminent in ageing and neurodegenerative disorders?

Bamshad, Chia; Najafi-Ghalehlou, Nima; Pourmohammadi-Bejarpasi, Zahra; Tomita, Kazuo; Kuwahara, Yoshikazu; Sato, Tomoaki; Feizkhah, Alireza; Roushnadeh, Amaneh Mohammadi; Roudkenar, Mehryar Habibi

doi:10.1007/s13577-022-00833-y

Cited by 11 publications

(6 citation statements)

References 199 publications

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“…• ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH), as well as several RNS [35]. Complex I in the mitochondrial respiratory chain plays an important role in this context.…”

Section: Internal Triggers Of Osmentioning

confidence: 99%

“…Even a partial suppression of complex I increases mitochondrial ROS production, creating a "vicious circle" [36]. Numerous studies have shown that mitochondria-derived free radicals play a significant role in the process of cellular senescence and the development of aging-related diseases [35]. With the aging of the body, mitochondrial function deteriorates, which leads to increased ROS production and OS induction.…”

Section: Internal Triggers Of Osmentioning

confidence: 99%

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Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

Yang,

Luo,

Tian

et al. 2024

Antioxidants

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Under normal physiological conditions, reactive oxygen species (ROS) are produced through redox reactions as byproducts of respiratory and metabolic activities. However, due to various endogenous and exogenous factors, the body may produce excessive ROS, which leads to oxidative stress (OS). Numerous studies have shown that OS causes a variety of pathological changes in cells, including mitochondrial dysfunction, DNA damage, telomere shortening, lipid peroxidation, and protein oxidative modification, all of which can trigger apoptosis and senescence. OS also induces a variety of aging-related diseases, such as retinal disease, neurodegenerative disease, osteoarthritis, cardiovascular diseases, cancer, ovarian disease, and prostate disease. In this review, we aim to introduce the multiple internal and external triggers that mediate ROS levels in rodents and humans as well as the relationship between OS, aging, and aging-related diseases. Finally, we present a statistical analysis of effective antioxidant measures currently being developed and applied in the field of aging research.

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“…• ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH), as well as several RNS [35]. Complex I in the mitochondrial respiratory chain plays an important role in this context.…”

Section: Internal Triggers Of Osmentioning

confidence: 99%

Section: Internal Triggers Of Osmentioning

confidence: 99%

Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

Yang,

Luo,

Tian

et al. 2024

Antioxidants

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“…Several research studies are focusing on Drp1 PTMs in fission. According to recent findings, Drp1 controls the dynamics of the fission process by moving from the cytosol to the OMM, where it interacts with other proteins that are part of the fission machinery, such as Fis1, Mff, Mid49, and Mid51 [ 27 , 28 ]. Table 1 presents critical information about the locations and molecular functions of major mitochondrial fission proteins.…”

Section: Mitochondrial Fissionmentioning

confidence: 99%

The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy

Zerihun

Sukumaran

Qvit

2023

IJMS

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Mitochondria, the membrane-bound cell organelles that supply most of the energy needed for cell function, are highly regulated, dynamic organelles bearing the ability to alter both form and functionality rapidly to maintain normal physiological events and challenge stress to the cell. This amazingly vibrant movement and distribution of mitochondria within cells is controlled by the highly coordinated interplay between mitochondrial dynamic processes and fission and fusion events, as well as mitochondrial quality-control processes, mainly mitochondrial autophagy (also known as mitophagy). Fusion connects and unites neighboring depolarized mitochondria to derive a healthy and distinct mitochondrion. In contrast, fission segregates damaged mitochondria from intact and healthy counterparts and is followed by selective clearance of the damaged mitochondria via mitochondrial specific autophagy, i.e., mitophagy. Hence, the mitochondrial processes encompass all coordinated events of fusion, fission, mitophagy, and biogenesis for sustaining mitochondrial homeostasis. Accumulated evidence strongly suggests that mitochondrial impairment has already emerged as a core player in the pathogenesis, progression, and development of various human diseases, including cardiovascular ailments, the leading causes of death globally, which take an estimated 17.9 million lives each year. The crucial factor governing the fission process is the recruitment of dynamin-related protein 1 (Drp1), a GTPase that regulates mitochondrial fission, from the cytosol to the outer mitochondrial membrane in a guanosine triphosphate (GTP)-dependent manner, where it is oligomerized and self-assembles into spiral structures. In this review, we first aim to describe the structural elements, functionality, and regulatory mechanisms of the key mitochondrial fission protein, Drp1, and other mitochondrial fission adaptor proteins, including mitochondrial fission 1 (Fis1), mitochondrial fission factor (Mff), mitochondrial dynamics 49 (Mid49), and mitochondrial dynamics 51 (Mid51). The core area of the review focuses on the recent advances in understanding the role of the Drp1-mediated mitochondrial fission adaptor protein interactome to unravel the missing links of mitochondrial fission events. Lastly, we discuss the promising mitochondria-targeted therapeutic approaches that involve fission, as well as current evidence on Drp1-mediated fission protein interactions and their critical roles in the pathogeneses of cardiovascular diseases (CVDs).

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“…The mitochondria perform a variety of household tasks such as producing energy from the metabolism of nutrients, oxidation of metabolites via the Krebs cycle, and oxidation of fatty acids, oxidative phosphorylation (OXPHOS). It also maintains calcium homeostasis, produces scavenging-free ions, and regulates cell differentiation and cell death (Bamshad et al, 2023).…”

Section: Role Of Mitochondria In Neurodegenera-tive Disordersmentioning

confidence: 99%

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Sajid,

Abbas,

Khan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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The phrase "neurodegenerative diseases" refers to conditions that cause a major loss of neurons, both structurally and functionally. Neurodegenerative diseases are serious life-threatening in which neural cells in the brain stop working or die. One of the most recently discovered pathogenic processes in the genesis of neurological illnesses is mitochondrial dysfunction. Mitochondria play a significant role in various cellular processes such as the production of ATP, intracellular calcium, and generation of reactive oxygen species and improper function leads to diseases. Oxidative stress and aging are two other prevalent etiologies of neurological diseases. Several side effects have emerged as a result of current treatment methods and the progressive nature of illnesses, prompting patients to switch to other medications. The helpful impact of medicinal plants in these situations has been attributed to their demonstration through several cellular and molecular processes. Traditional plants have a few neuroprotective mechanisms: they reduce inflammatory responses, regulate pro-inflammatory cytokines' functional aspects such as tumor growth, and enhance antioxidant qualities. Plant prevention strategies for these diseases heavily rely on variations in transcription and transduction pathways. Some of the therapeutic herbs for preventing neurological disorders are Panax ginseng, Curcuma longa, Zingiber officinale, Ginkgo biloba, and Utrica diocia, etc., have shown antioxidant as well as anti-inflammatory effects and also show a promising tool for treating neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, multiple sclerosis, and epilepsy. Medicinal plants contain various phytochemical constituents that improve oxidative stress, reduce mitochondrial damage, and protect against brain damage. In short, use of whole plants or parts of medicinal plants from roots to seeds extracted chemicals are used to prevent neurodegenerative illnesses.

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Mitochondria: how eminent in ageing and neurodegenerative disorders?

Cited by 11 publications

References 199 publications

Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

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