Mitochondria malfunctions as mediators of stem-cells’ related carcinogenesis: A hypothesis that supports the highly conserved profile of carcinogenesis

Hatzi, Vasiliki I.; Terzoudi, Georgia I.; Pantelias, Gabriel E.; Makropoulos, Vasilios

doi:10.1016/j.mehy.2012.10.002

Cited by 3 publications

(1 citation statement)

References 66 publications

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“…Mitochondria, the highly conserved organelles responsible for cellular bioenergetic activity, might play a crucial role in carcinogenesis [ 11 ]. Compared to the nuclear genome, mitochondrial DNA (mtDNA) has a modified genetic code, a paucity of introns, and the absence of histone protection.…”

Section: Introductionmentioning

confidence: 99%

Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

et al. 2015

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BackgroundThe proliferating activity of a single leukemia stem cell and the molecular mechanisms for their quiescent property remain unknown, and also their prognostic value remains a matter of debate. Therefore, this study aimed to demonstrate the quiescence property and molecular signature of leukemia stem cell and their clinicopathological implications.MethodsSingle cell sorting and culture were performed in the various sets of hematopoietic stem cells including CD34+CD38- acute myeloid leukemia (AML) cell population (ASCs) from a total of 60 patients with AML, and 11 healthy controls. Their quiescence related-molecular signatures and clinicopathological parameters were evaluated in AML patients.ResultsSingle cell plating efficiency of ASCs was significantly lower (8.6%) than those of normal hematopoietic stem cells i.e.: cord blood, 79.0%; peripheral blood, 45.3%; and bone marrow stem cell, 31.1%. Members of the TGFβ super-family signaling pathway were most significantly decreased; as well as members of the Wnt, Notch, pluripotency maintenance and hedgehog pathways, compared with non ASC populations. mtDNA copy number of ASCs was significantly lower than that of corresponding other cell populations. However, our data couldn’t support the prognostic value of the ASCs in AML.ConclusionsASCs showed remarkable lower plating efficiency and slower dividing properties at the single cell level. This quiescence is represented as a marked decrease in the mtDNA copy number and also linked with down-regulation of genes in various molecular pathways.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-015-1233-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

et al. 2015

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Mitochondrial emitted electromagnetic signals mediate retrograde signaling

2015

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Exploring the interplay between iron metabolism imbalance and esophageal cancer

Qi,

2024

Oncologie

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Iron metabolism plays a crucial role in various physiological processes, and its dysregulation has been implicated in many cancers. Epidemiological studies have confirmed a significant correlation between iron overload and an increased risk of oesophageal cancer. The purpose of this review is to investigate the relationship between iron metabolism imbalance and oesophageal cancer and to explore the potential application of iron metabolism regulatory mechanisms in the treatment of oesophageal cancer. This paper details the physiological mechanisms that regulate cellular iron homeostasis, including absorption, storage, utilization, and excretion and focuses on changes in iron homeostasis in oesophageal cancer cells. In addition, the paper discusses the multifaceted roles of iron in tumourigenesis, progression and metastasis, as well as the impact of iron metabolism in the tumour microenvironment. Finally, this paper discusses the potential impact of ferroptosis on cancer cell survival, highlights the importance of iron metabolism in oesophageal cancer, and provides new ideas for the prevention, diagnosis and treatment of oesophageal cancer. Future research should further elucidate the specific role of iron metabolism in esophageal cancer pathogenesis and explore new therapeutic approaches using these mechanisms for more effective treatment strategies.

show abstract

Mitochondria malfunctions as mediators of stem-cells’ related carcinogenesis: A hypothesis that supports the highly conserved profile of carcinogenesis

Cited by 3 publications

References 66 publications

Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

Mitochondrial emitted electromagnetic signals mediate retrograde signaling

Exploring the interplay between iron metabolism imbalance and esophageal cancer

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