2016
DOI: 10.1371/journal.pone.0156818
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Mitochondria-Mediated Anticancer Effects of Non-Thermal Atmospheric Plasma

Abstract: Non-thermal atmospheric pressure plasma has attracted great interest due to its multiple potential biomedical applications with cancer treatment being among the most urgent. To realize the clinical potential of non-thermal plasma, the exact cellular and molecular mechanisms of plasma effects must be understood. This work aimed at studying the prostate cancer specific mechanisms of non-thermal plasma effects on energy metabolism as a central regulator of cell homeostasis and proliferation. It was found that can… Show more

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Cited by 24 publications
(30 citation statements)
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“…In glioblastoma cells, PAM with high concentrations of H 2 O 2 and NO 2 induced down-regulation of the AKT and extracellular signalregulated kinase (ERK) signaling pathways, inhibition of the glycolysis pathway and enhancement of the pentose phosphate pathway (11,18). Prostate cancer cells, with a background of high energy metabolism and higher oxidative conditions, cause them to be more vulnerable to plasmainduced injury (19). The growth of human colorectal tumor spheroids treated with PAM in vitro was inhibited through ATP depletion, mitochondrial oxidative stress, necrosis and apoptosis (12).…”
mentioning
confidence: 99%
“…In glioblastoma cells, PAM with high concentrations of H 2 O 2 and NO 2 induced down-regulation of the AKT and extracellular signalregulated kinase (ERK) signaling pathways, inhibition of the glycolysis pathway and enhancement of the pentose phosphate pathway (11,18). Prostate cancer cells, with a background of high energy metabolism and higher oxidative conditions, cause them to be more vulnerable to plasmainduced injury (19). The growth of human colorectal tumor spheroids treated with PAM in vitro was inhibited through ATP depletion, mitochondrial oxidative stress, necrosis and apoptosis (12).…”
mentioning
confidence: 99%
“…Ispitivanje svojstava CAP-a izuzetno je zahtjevno i još uvijek je predmetom mnogobrojnih istraživanja. Dodatan problem je to što ne postoji dogovorom prihvaćena definicija primljene/predane doze te se o njoj najčešće govori u smislu duljine trajanja tretmana, odnosno vremenske izloženosti djelovanju plazme 5,10 . Primjena CAP u biomedicini podrazumijeva rad u vlažnom okruženju.…”
Section: Plazma U Fiziciunclassified
“…In vivo studije na mišjim modelima također su dale vrlo obećavajuće rezultate 45,50,54 . Dosadašnje studije opravdavaju optimizam vezan uz moguću terapiju tumora CAP-om, no ne treba smetnuti s uma da ROS imaju negativan utjecaj i na zdrave stanice te da mehanizam plazmom inducirane apoptoze još uvijek nije razjašnjen 10,44 . Da bi se tretman CAP-om razvio kao moguća terapija za tumore mora se, uz dokazanu selektivnost tj.…”
Section: Moguća Primjena U Terapiji Tumoraunclassified
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“…Over the last two decades, potential applications have extended from eradicating microorganisms during wound healing to inactivating tumor cells [2]. Today, effective killing of the latter has been demonstrated for different types of cancers including head and neck [3][4][5], leukemia [6][7][8], glioblastoma [9][10][11], pancreas [12][13][14], malignant melanoma [15][16][17], colon [18][19][20], prostate [21][22][23], osteosarcoma [24][25][26], and ovarian [27][28][29]. It has been established the ROS/RNS are the main drivers of antitumor plasma effects [30][31][32].…”
Section: Introductionmentioning
confidence: 99%