Mitochondria – More than just batteries for cellular function

Reuter, Stefanie

doi:10.1111/apha.13852

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Mitochondria, the well-known cellular powerhouse, are subcellular organelles that are responsible for most of the cellular energy production through the synthesis of adenosine 5′-triphosphate (ATP). They are also essential for numerous cellular processes, − including calcium signaling, cell growth and differentiation, cell cycle control, and cell death. Therefore, mitochondrial defects or dysfunctions are involved in a wide number of diseases. ,− Consequently, there is considerable interest in delivering bioactive molecules selectively to mitochondria in order to interfere with mitochondrial processes, but mitochondria is known for its highly hydrophobic inner membrane and negative membrane potential, which result in limited diffusion.…”

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confidence: 99%

Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery

Guiraud,

Ali,

Gabrieli-Magot

et al. 2024

ACS Med. Chem. Lett.

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Herein, we report the design, the synthesis, and the study of novel triphenyl phosphonium-based nucleoside conjugates. 2′-Deoxycytidine was chosen as nucleosidic cargo, as it allows the introduction of fluorescein on the exocyclic amine of the nucleobase and grafting of the vector was envisaged through the formation of a biolabile ester bond with the hydroxyl function at the 5′-position. Compound 3 was identified as a potential nucleoside prodrug, showing ability to be internalized efficiently into cells and to be colocalized with mitochondria.

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mentioning

confidence: 99%

Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery

Guiraud,

Ali,

Gabrieli-Magot

et al. 2024

ACS Med. Chem. Lett.

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Cardiovascular diseases and mitochondrial transplantation

Borisov,

McCusker,

McIntyre

et al. 2024

Mitochondrial Transplantation and Transfer

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Progress in the mechanism of functional dyspepsia: roles of mitochondrial autophagy in duodenal abnormalities

Zhong,

Du,

Niu

et al. 2024

Front. Med.

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Mitochondria are the main source of energy for cellular activity. Their functional damage or deficiency leads to cellular deterioration, which in turn triggers autophagic reactions. Taking mitochondrial autophagy as a starting point, the present review explored the mechanisms of duodenal abnormalities in detail, including mucosal barrier damage, release of inflammatory factors, and disruption of intracellular signal transduction. We summarized the key roles of mitochondrial autophagy in the abnormal development of the duodenum and examined the in-depth physiological and pathological mechanisms involved, providing a comprehensive theoretical basis for understanding the pathogenesis of functional dyspepsia. At present, it has been confirmed that an increase in the eosinophil count and mast cell degranulation in the duodenum can trigger visceral hypersensitive reactions and cause gastrointestinal motility disorders. In the future, it is necessary to continue exploring the molecular mechanisms and signaling pathways of mitochondrial autophagy in duodenal abnormalities. A deeper understanding of mitochondrial autophagy provides important references for developing treatment strategies for functional dyspepsia, thereby improving clinical efficacy and patient quality of life.

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Mitochondria – More than just batteries for cellular function

Cited by 3 publications

References 20 publications

Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery

Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery

Cardiovascular diseases and mitochondrial transplantation

Progress in the mechanism of functional dyspepsia: roles of mitochondrial autophagy in duodenal abnormalities

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