Mitochondria-targeted liposome-enveloped covalent organic framework co-delivery system for enhanced tumor therapy

Zhang, Lina; Jia, Yutao; Han, Ho Jae; Wang, Mi; Wang, Jing

doi:10.1016/j.micromeso.2022.112198

Cited by 9 publications

(7 citation statements)

References 40 publications

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“…[ 93 ] Encouraged by it, a mitochondria‐targeted co‐DDS was developed by utilizing methoxylated COF as a carrier in Wang's group. [ 94 ] In this regard, CPT which can play an important role in mitochondrial oxidative damage was co‐loaded by using DOX‐lipid drug. The double drug loading of CPT/DOX was capable of raising the amount of active singlet oxygen species and improving anti‐tumor activity.…”

Section: The Utilization Of 3d Cof‐based Materials In Drug Releasementioning

confidence: 99%

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Mehvari,

Ramezanzade,

Asadi

et al. 2024

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The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs, particularly for aggressive and difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in drug delivery systems (DDS), due to their unique properties, including the metal‐free organic skeleton, predetermined structures and pore geometries, high porosity, large surface area, facile surface modification potential, and good biocompatibility. These characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise encapsulation. This review emphasizes the importance of donor‐acceptor‐based COFs, which provide channels for charge transportation, and we also explore how the π‐conjugated skeleton of COFs enhances its long‐acting fluorescent properties and facilitates drug uptake via cell endocytosis. While this review primarily focuses on recent advancements in COF‐based targeted DDS, it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential solutions. Further, it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells, improving treatment efficiency while reducing adverse side effects.

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Section: The Utilization Of 3d Cof‐based Materials In Drug Releasementioning

confidence: 99%

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Mehvari,

Ramezanzade,

Asadi

et al. 2024

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“…The COF@liposome significantly increased the level of reactive oxygen species in 4T1 cells, which eventually inhibited tumour growth in 4T1 cell-induced BALB/c mouse models. 177…”

Section: Drug Delivery Using Cofsmentioning

confidence: 99%

“…The COF@liposome significantly increased the level of reactive oxygen species in 4T1 cells, which eventually inhibited tumour growth in 4T1 cell-induced BALB/c mouse models. 177 Fang and Negeshi et al reported the synthesis of another very interesting and noteworthy COF (TUS-64) by linking 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TAPP) with 2,3,6,7,14,15-hexakis(4 0 -formylphenyl)triptycene (HFPTP) at 120 1C for 3 days in a solvent mixture with 2 : 3 molar ratio in 6 M aqueous acetic acid/1,4-dioxane/mesitylene (1 : 3 : 7, v/v). Its BET surface area was calculated to be 1632 m 2 g À1 .…”

Section: Cofs As Multiple Drug Carriermentioning

confidence: 99%

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Drug delivery using biocompatible covalent organic frameworks (COFs) towards a therapeutic approach

Ghosh,

Banerjee

2023

Chem. Commun.

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“…COF membranes are generally fabricated as a) pristine self‐standing membranes, b) mixed matrix membranes (MMMs), and c) thin film composite (TFC) membranes (MMMs and TFC membranes are categories of composite membranes). Several methods have been developed for the fabrication of COF membranes, including in‐situ growth, interfacial polymerization (IP), unidirectional diffusion, layer‐by‐layer (LbL) stacking, solution casting, electro‐deposition, etc [29,42] . Pristine self‐standing COF membranes often suffer from several limitations such as defects, low porosity, limited chemical stability, variable thickness, fragile nature, and low mechanical stability under high pressure and temperature.…”

Section: Fundamentals Of Cof Composite Membranesmentioning

confidence: 99%

Covalent Organic Framework‐derived Composite Membranes for Water Treatment

Elmerhi,

Kumar,

Abi Jaoude

et al. 2023

Chemistry An Asian Journal

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Water treatment has experienced a surge in the adoption of membrane separation technology. Covalent organic frameworks (COFs), a class of metal‐free and open‐framework materials, have emerged as potential membrane materials owing to their interconnected periodic porosity, tunability, and chemical stability. However, the challenges associated with processing COF powders into self‐standing membranes have spurred the emergence of COF composite membranes. This review article highlights the rationale behind developing COF composite membranes and their categories, including mixed matrix membranes (MMMs) and thin film composite (TFC) membranes. The common fabrication techniques of each category are presented. In addition, the influence of COF additives on the performance of the resultant composite membranes is systematically discussed, with a focus on the recent progress in applying COF composite membranes in the separation of different categories of water pollutants, including organic ions/molecules, toxic solvents, proteins, toxic heavy metals, and radionuclides.

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Mitochondria-targeted liposome-enveloped covalent organic framework co-delivery system for enhanced tumor therapy

Cited by 9 publications

References 40 publications

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Drug delivery using biocompatible covalent organic frameworks (COFs) towards a therapeutic approach

Covalent Organic Framework‐derived Composite Membranes for Water Treatment

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