Mitochondria targeted liposomes of metformin for improved anticancer activity: Preparation and evaluation

Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery

“…TPP-phospholipids (with dioleoyl, dimyristoyl or dipalmitoyl groups) were used as conjugates for liposome modification to provide effective mitochondrial targeting. 48,49 Such a TPP-liposome system was more biocompatible compared to the patterns modified with stearyl triphenyl phosphonium bromide (STPPliposomes), in particular, they did not cause loss of membrane integrity. 50 Even more inspiring examples are liposomal systems containing triphenylphosphonium drug lipids that offer numerous benefits.…”