Mitochondrial and immune response dysregulation in melanoma recurrence

Mitochondrial dysfunction and immune suppression in BRAF V600E‐mutated metastatic melanoma

“…1 Building upon our previous insights into melanoma's molecular dynamics, this study delves deeper into mitochondrial proteome alterations associated with the BRAF V600E mutation. 2,3 Through comprehensive analysis of proteomic data from a total of 127 melanoma lymph node metastases, sourced from the Human Melanoma Proteome Atlas project, we demonstrate how specific mitochondrial disruptions enhance melanoma proliferation and facilitate progression towards distant metastasis (Figure 1A) . 4 By investigating the specific role of mitochondrial dysfunction in the progression and immune evasion of BRAF V600E-mutated metastatic melanoma, we aim to elucidate the molecular mechanisms that drive aggressive melanoma behaviour and identify potential targets for precision medicine.…”

“…Natália Pinto de Almeida 1,2,3 Ágnes Judit Jánosi 4 Runyu Hong 5,6 Ahmad Rajeh 7 Fábio Nogueira 1,2 Leticia Szadai 4 Beata Szeitz 8 Indira Pla Parada 9 Viktória Doma 10,11 Nicole Woldmar 3 Jéssica Guedes 1,2,9 Zsuzsanna Újfaludi 12,13 Aron Bartha 14 Yonghyo Kim 15,16 Charlotte Welinder 16 Bo Baldetorp 16 Lajos Vince Kemény 11,17,18 Zoltan Pahi 12 Guihong Wan 7,19 Nga Nguyen 7 Tibor Pankotai 12,13,20 Balázs Győrffy 14,21,27 Krzysztof Pawłowski 9,22,23 Peter Horvatovich 3,24 Attila Marcell Szasz 14 Aniel Sanchez 9 Magdalena Kuras 3,9 Jimmy Rodriguez Murillo 3 Lazaro Betancourt 9 Gilberto B. Domont 2 Yevgeniy R. Semenov 7 Kun-Hsing Yu 19 Ho Jeong Kwon 25 István Balázs Németh 4 David Fenyő 5,6 Elisabet Wieslander 9 György Marko-Varga 3,25,26 Jeovanis Gil…”