2024
DOI: 10.1101/2024.06.07.598027
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Mitochondrial Antiviral Pathways Control Anti-Hiv Responses and Ischemic Stroke Outcomes via the Rig-1 Signaling and Innate Immunity Mechanisms

Silvia Torices,
Thaidy Moreno,
Sita Ramaswamy
et al.

Abstract: SUMMARYOccludin (ocln) is one of the main regulatory cells of the blood-brain barrier (BBB). Ocln silencing resulted in alterations of the gene expression signatures of a variety of genes of the innate immunity system, including IFN-stimulated genes (ISGs) and the antiviral retinoic acid-inducible gene-1 (RIG-1) signaling pathway, which functions as a regulator of the cytoplasmic sensors upstream of the mitochondrial antiviral signaling protein (MAVS). Indeed, we observed dysfunctional mitochondrial bioenerget… Show more

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