Mitochondrial biogenesis in exercise and in ageing☆

Viña, José; Gómez-Cabrera, Mari Carmen; Borrás, Consuelo; Froio, T; Sanchís-Gomar, Fabián; Martínez-Bello, Vladimir E.; Pallardó, Federico V.

doi:10.1016/j.addr.2009.06.006

Cited by 205 publications

(146 citation statements)

References 30 publications

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“…Vina et al (2009) concluded that exercise, and particularly aerobic exercise, activated mitochondriogenesis in young animals, although its influence on older animals required further investigation. Eight weeks of treadmill training in a murine model augmented mitochondrial function, as reflected by increased mitochondrial enzyme activities, maximal rate of ATP synthesis in isolated mitochondria, and whole-body maximal O2 uptake (Chow et al, 2007).…”

Section: Exercise and Its Effect On Mitochondriamentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

532

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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Section: Exercise and Its Effect On Mitochondriamentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

532

412

View full text Add to dashboard Cite

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“…In addition, PGC‐1α extends health span and life span of a mouse model of premature aging arising from mitochondria defects (Sahin et al., 2011). Importantly, in line with the mitochondrial decline, PGC‐1α expression decreases during muscle aging in different species, including humans (Ghosh et al., 2011; Kang, Chung, Diffee, & Ji, 2013; Short et al., 2005; Vina et al., 2009). Moreover, PGC‐1α improves various muscle disorders, for example, denervation‐induced fiber atrophy (Sandri et al., 2006) or Duchenne muscular dystrophy (Handschin, Kobayashi et al., 2007).…”

Section: Introductionmentioning

confidence: 99%

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

et al. 2017

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SummaryThe age‐related impairment in muscle function results in a drastic decline in motor coordination and mobility in elderly individuals. Regular physical activity is the only efficient intervention to prevent and treat this age‐associated degeneration. However, the mechanisms that underlie the therapeutic effect of exercise in this context remain unclear. We assessed whether endurance exercise training in old age is sufficient to affect muscle and motor function. Moreover, as muscle peroxisome proliferator‐activated receptor γ coactivator 1α (PGC‐1α) is a key regulatory hub in endurance exercise adaptation with decreased expression in old muscle, we studied the involvement of PGC‐1α in the therapeutic effect of exercise in aging. Intriguingly, PGC‐1α muscle‐specific knockout and overexpression, respectively, precipitated and alleviated specific aspects of aging‐related deterioration of muscle function in old mice, while other muscle dysfunctions remained unchanged upon PGC‐1α modulation. Surprisingly, we discovered that muscle PGC‐1α was not only involved in improving muscle endurance and mitochondrial remodeling, but also phenocopied endurance exercise training in advanced age by contributing to maintaining balance and motor coordination in old animals. Our data therefore suggest that the benefits of exercise, even when performed at old age, extend beyond skeletal muscle and are at least in part mediated by PGC‐1α.

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“…Thus, to identify genotypes related to mitochondriogenesis (involving the PPARD-PPARGC1A-NRF-TFAM pathway) is of interest from a broader health perspective in aged people because these genotypes theoretically could be associated with muscle capacity and frailty in the elderly. Indeed, mitochondriogenesis is critical for the normal function of cells and the PPARD-PPARGC1A-NRF-TFAM pathway is impaired by chronic physical inactivity (Vina, Gomez-Cabrera, Borras, Froio, Sanchis-Gomar, Martinez-Bello & Pallardo, 2009a) and ageing (Hood, 2009). Reduced mitochondriogenesis can result in reduced muscle aerobic capacity (which is in itself an important health indicator), increased tendency for mitochondrially-mediated apoptosis, and, ultimately, accelerated sarcopenia (Hood, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…As more individuals live longer, we should try to elucidate the mechanisms involved in healthy ageing and preserving functional independence in later life. With regards to this, mitochondria are one of the most important organelles for understanding the ageing process (Vina, Gomez-Cabrera, Borras, Froio, Sanchis-Gomar, Martinez-Bello, & Pallardo, 2009b). A constant renewal of these organelles is crucial for maintaining their normal function.…”

Section: Introductionmentioning

confidence: 99%

Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are neither associated with muscle characteristics nor physical performance in elderly. [Variaciones genéticas en la vía de la mitocondriogénesis PPARD-PPARGC1A-NRF-TFAM no están asociadas ni con características musculares ni con rendimiento físico en personas mayores].

Garatachea¹,

Santiago²,

Yvert³

et al. 2015

Rev. int. cienc. deporte

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Variaciones genéticas en la vía de la mitocondriogénesis PPARD-PPARGC1A-NRF-TFAM no están asociadas ni con características musculares ni con rendimiento físico en personas mayores We studied the influence of genetic polymorphisms involved in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway (rs6949152, rs12594956, rs2267668, rs8192678, and rs1937) on muscle phenotypes (thigh muscles' cross-sectional, maximal handgrip-strength and 30-second chair stand-test) and Barthel index in Caucasian (Spanish) community-dwelling old people (n=75, 21 men, 54 women; 71-94 years). We found no significant genetic associations with the studied phenotypes. Multiple, complex gene-environment and gene-gene interactions which are yet to be determined are likely to play a more determinant role.Key words: ageing; mitochondria; muscle. AbstractCorrespondence/correspondencia: Nuria Garatachea-Vallejo Faculty of Health and Sport Science, Universidad de Zaragoza. Spain Email: nuria.garatachea@unizar.es Se estudió la influencia de los polimorfismos genéticos implicados en la vía de mitocondriogénesis PPARD-PPARGC1A-NRF-TFAM (rs6949152, rs12594956, rs2267668, rs8192678 y rs1937) en distintos fenotipos musculares (sección transversal muscular del muslo, fuerza máxima de prensión manual y 30 segundos de sentarse-levantarse de una silla) y en el índice de Barthel en personas mayores caucási-cas (españoles) (n = 75, 21 hombres, 54 mujeres; 71 a 94 años). No se encontraron asociaciones gené-ticas significativas con los fenotipos estudiados. Interacciones múltiples, complejos gen-ambiente y relaciones gen-gen aún no determinadas podrían desempeñar un papel más determinante.Palabras clave: envejecimiento; mitocondrias; músculo.Resumen Received: July 11, 2014 / Accepted: January 17, 2015 http://dx.doi.org/10.5232/ricyde2015.04101 Garatachea, N.; Santiago, C.; Yvert, T.; Verde-Rello, Z.; Fiuza-Luces, C.; . Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are not associated neither muscle characteristics nor physical performance in elderly. RICYDE. Revista internacional de ciencias del deporte, 41(11),[196][197][198][199][200][201][202][203][204][205][206][207][208]

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Mitochondrial biogenesis in exercise and in ageing☆

Cited by 205 publications

References 30 publications

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

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