2024
DOI: 10.1101/2024.02.01.578153
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Mitochondrial Ca2+efflux controls neuronal metabolism and long-term memory across species

Anjali Amrapali Vishwanath,
Typhaine Comyn,
Chaitanya Chintaluri
et al.

Abstract: While impairing neuronal metabolism limits brain performance, it remains poorly understood whether enhancing metabolism in neurons, in contrast, could boost brain function. We find that reducing the expression of the mitochondrial H+/Ca2+exchanger Letm1 results in increased Ca2+retention in the mitochondrial matrix of firing neurons, which overactivates neuronal metabolism in flies and rodents. We find that upscaled metabolic states in active neurons of central memory circuits of flies and mice enable storing … Show more

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