2005
DOI: 10.1196/annals.1341.012
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Mitochondrial Calcium Signaling and Energy Metabolism

Abstract: A computational model of energy metabolism in the mammalian ventricular myocyte is developed to study the effect of cytosolic calcium (Ca(2+)) transients on adenosine triphosphate (ATP) production. The model couples the Jafri-Dudycha model for tricarboxylic acid cycle regulation to a modified version of the Magnus-Keizer model for the mitochondria. The fluxes associated with Ca(2+) uptake and efflux (i.e., the Ca(2+) uniporter and Na(+)-Ca(2+) exchanger) and the F(1)F(0)-ATPase were modified to better model he… Show more

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Cited by 51 publications
(49 citation statements)
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“…These processes include the import and export of metabolites and inorganic ions such as phosphate, sodium, potassium and calcium (Nguyen and Jafri 2005;Szabò et al 2005). Ionic calcium (Ca 2+ ) is a highly versatile intracellular signalling molecule that regulates a variety of cellular processes (Berridge et al 2003).…”
Section: Metabolite and Ion Balancementioning
confidence: 99%
“…These processes include the import and export of metabolites and inorganic ions such as phosphate, sodium, potassium and calcium (Nguyen and Jafri 2005;Szabò et al 2005). Ionic calcium (Ca 2+ ) is a highly versatile intracellular signalling molecule that regulates a variety of cellular processes (Berridge et al 2003).…”
Section: Metabolite and Ion Balancementioning
confidence: 99%
“…An earlier study (65) incorporated a rudimentary model for the energy coupling between the cytosolic and mitochondrial metabolism in the ␤-cell; however, it is far too simplified to be used to address the questions posed in the present study. Other previous models concerning the mitochondrial shuttles and the TCA cycle (21,44,71) were for other cell types and do not include all enzymatic reactions relevant to ␤-cell biochemistry.…”
Section: Model Descriptionmentioning
confidence: 99%
“…A large number of mitochondrial models describing a wide range of mitochondrial functions, including energy transduction (10 -12, 50, 61, 69, 100), Ca 2ϩ signaling (31,86,134), and respiratory regulation (59,60,133), can be found in the literature. The increasing accessibility of computational power and availability of data have made the building of larger and more comprehensive models possible.…”
Section: Quantitative Analysis: Model Validation and Functional Statementioning
confidence: 99%