Mitochondrial Changes in Gastric Mucosa and Liver under Neurogenic Dystrophies

Anichkov, S. V.; Zavodskaya, I. S.; Korkhov, Vladimir

doi:10.1159/000135937

Cited by 2 publications

(3 citation statements)

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“…The reduction of monoamines in the gastric mucosa of stressed rats (electrical stimulation and immobilization) is accompanied by the appearance of ulcers and erosion in this organ (2). Amines physiologically stimulate the major pepsin-forming cells and facilitate the return of normal gastric secretory function after prolonged, exhaustive hypersecretion (3 ,8 ,9 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Stress and Drugs on the Catecholamine and Pepsin Concentrations in Stomach Wall of Rat

Grechishkin¹

1975

Pharmacology

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Reserpine, serotonin, and histamine as well as stress were employed to produce dystrophic lesions in the gastric mucosa of rats. Analysis of stomach tissues revealed that agencies which reduced catecholamine concentration also decreased endogenous levels of pepsinogen. Concentrations of the zymogen were increased after parenteral administration of dopa, but were not changed by injections of α-methyl-dopa. The evidence supports the suggestion that catecholamines participate in the control of pepsin production and are involved in the secretory function of the stomach.

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Section: Discussionmentioning

confidence: 99%

Effects of Stress and Drugs on the Catecholamine and Pepsin Concentrations in Stomach Wall of Rat

Grechishkin¹

1975

Pharmacology

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“…The pharmacological analysis of neurogenic dystrophies performed in our laboratory made apparent their reflex origin and allowed it to be established that the group of sympathetic fibres is the efferent part of the reflex arc partici pating in dystrophies [4,16].…”

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confidence: 99%

“…Evidence of this is the preventive action against gastric wall dystrophies of sympatholytics: sympatholytine, guanethidine and phepracet1 [2,16,17], and also of the ganglion blocking agent hexamethonium, inhibiting in a large dose the parasympathetic as well as the sympathetic ganglia [4].…”

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confidence: 99%