Mitochondrial Channels in Neurodegeneration

Peixoto, Pablo M.; Kinnally, Kathleen W.; Pavlov, Evgeny

doi:10.1002/9781119017127.ch3

The Functions, Disease‐Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria 2015

DOI: 10.1002/9781119017127.ch3

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Mitochondrial Channels in Neurodegeneration

Pablo M. Peixoto

Kathleen W. Kinnally

Evgeny Pavlov

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2022

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Mitochondrial Ion Channels in Aging and Related Diseases

Ashrafuzzaman

2022

CAS

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Transport of materials and information across cellular boundaries, such as plasma, mitochondrial and nuclear membranes, happens mainly through varieties of ion channels and pumps. Various biophysical and biochemical processes play vital roles. The underlying mechanisms and associated phenomenological lipid membrane transports are linked directly or indirectly to the cell health condition. Mitochondrial membranes (mitochondrial outer membrane (MOM) and mitochondrial inner membrane (MIM)) host crucial cellular processes. Their malfunction is often found responsible for the rise of cell-originated diseases, including cancer, Alzheimer’s, neurodegenerative disease, etc. A large number of ion channels active across MOM and MIM are known to belong to vital cell-based structures found to be linked directly to cellular signaling. Hence their malfunctions are often found to contribute to abnormalities in intracellular communication, which may even be associated with the rise of various diseases. In this article, the aim is to pinpoint ion channels that are directly or indirectly linked to especially aging and related abnormalities in health conditions. An attempt has been made to address the natural structures of these channels, their mutated conditions, and the ways we may cause interventions in their malfunctioning. The malfunction of ion channel subunits, including especially various proteins, involved directly in channel formation and/or indirectly in channel stabilization, leads to the rise of various channel-specific diseases, which are known as channelopathies. Channelopathies in aging will be discussed briefly. This mini-review may be found as an important reference for drug discovery scientists dealing with aging-related diseases.

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Mitochondrial Ion Channels in Aging and Related Diseases

Ashrafuzzaman

2022

CAS

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Mitochondrial Channels in Neurodegeneration

Cited by 1 publication

References 252 publications

Mitochondrial Ion Channels in Aging and Related Diseases

Mitochondrial Ion Channels in Aging and Related Diseases

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