Mitochondrial DNA ?common? deletion in H�rthle cell lesions of the thyroid

Abstract

References 1. Yun K, Merrie AEH, Gunn J, Phillips LV, McCall JL. Keratin 20is a speci®c marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.

Oncocytic Meningioma: Case Report of a Rare Meningioma Variant

“…12 In oncocytic neoplasms, the histological appearance is thought to be caused by a disequilibrium between mitochondrial proliferation and mitochondrial destruction and/or cell division, resulting in an accumulation of mitochondria. 13 Furthermore, oncocytic thyroid tumors are also reported to have a higher prevalence of large deletions of mitochondrial DNA (mtDNA) and mutations of mtDNA genes that code for oxidative phosphorylation proteins, which could be related to energy production defects. 14 The mitochondrial abnormalities may contribute to this predisposition to necrosis instead of apoptosis 14 and is a possible explanation for the uncommon pattern of vascularization of this oncocytic meningioma and the reported tendency for bleeding and infarction, as has also been seen in this case.…”

Mitochondrial DNA Mutations in Differentiated Thyroid Cancer with Respect to the Age Factor

“…28 Mutations in mtDNA have so far been demonstrated in various types of human cancer 4,[31][32][33][34][35][36][37][38] and in non-malignant thyroid disorders. [39][40][41][42][43] Very few studies have analysed mutations of mtDNA in diseased thyroid tissue, such as Hashimoto's thyroiditis, thyroid tumours composed of oxiphilic cells, and thyroid carcinomas. Between 1991 and 1998, 4 studies on a total of 19 thyroid tumours were published.…”

“…[31][32][33][34][35][36][37][38] Only a few studies that analyzed mtDNA mutations in thyroid tissue have been published to date. 4,[39][40][41][42][43] We therefore investigated the significance and frequency of mtDNA mutations in PTCs and FTCs for age dependence in a group of patients with thyroid carcinoma. We focused on mtDNA mutations with respect to clinical differences and the prognostic impact of age for differentiated thyroid carcinomas.…”