Mitochondrial dysfunction and autophagy activation are associated with cardiomyopathy developed by extended methamphetamine self-administration in rats

Abdullah, Chowdhury S.; Remex, Naznin Sultana; Aishwarya, Richa; Nitu, Sadia; Kolluru, Gopi K.; Traylor, James; Hartman, Brandon; King, Judy A.; Bhuiyan, Mohammad Alfrad Nobel; Hall, Nicole; Murnane, Kevin S.; Goeders, Nicholas E.; Kevil, Christopher G.; Orr, A. Wayne; Bhuiyan, Md. Shenuarin

doi:10.1016/j.redox.2022.102523

Cited by 11 publications

(3 citation statements)

References 95 publications

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“…Methamphetamine and cocaine use are strongly associated with ASCVD development and progression ( 10 , 14 , 15 ). Yet the underlying mechanisms remain elusive ( 16 ). Surprisingly, the biological and clinical effects of methamphetamine and cocaine on PAD have received considerably little attention ( 10 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study

Ali,

Al-Yafeai,

Hossain

et al. 2024

Front. Cardiovasc. Med.

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BackgroundPeripheral artery disease (PAD) is on the rise worldwide, ranking as the third leading cause of atherosclerosis-related morbidity; much less is known about its trends in hospitalizations among methamphetamine and cocaine users.ObjectivesWe aim to evaluate the overall trend in the prevalence of hospital admission for PAD with or without the use of stimulant abuse (methamphetamine and cocaine) across the United States. Additionally, we evaluated the PAD-related hospitalizations trend stratified by age, race, sex, and geographic location.MethodsWe used the National Inpatient Sample (NIS) database from 2008 to 2020. The Cochran Armitage trend test was used to compare the trend between groups. Multivariate logistic regression was used to examine adjusted odds for PAD and CLI hospitalizations among methamphetamine and cocaine users.ResultsBetween 2008 and 2020, PAD-related hospitalizations showed an increasing trend in Hispanics, African Americans, and western states, while a decreasing trend in southern and Midwestern states (p-trend <0.05). Among methamphetamine users, an overall increasing trend was observed in men, women, western, southern, and midwestern states (p-trend <0.05). However, among cocaine users, PAD-related hospitalization increased significantly for White, African American, age group >64 years, southern and western states (p-trend <0.05). Overall, CLI-related hospitalizations showed an encouraging decreasing trend in men and women, age group >64 years, and CLI-related amputations declined for women, White patient population, age group >40, and all regions (p-trend <0.05). However, among methamphetamine users, a significantly increasing trend in CLI-related hospitalization was seen in men, women, White & Hispanic population, age group 26–45, western, southern, and midwestern regions.ConclusionsThere was an increasing trend in PAD-related hospitalizations among methamphetamine and cocaine users for both males and females. Although an overall decreasing trend in CLI-related hospitalization was observed for both genders, an up-trend in CLI was seen among methamphetamine users. The upward trends were more prominent for White, Hispanic & African Americans, and southern and western states, highlighting racial and geographic variations over the study period.

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Section: Introductionmentioning

confidence: 99%

Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study

Ali,

Al-Yafeai,

Hossain

et al. 2024

Front. Cardiovasc. Med.

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Section: Introductionmentioning

confidence: 99%

“…MA acts by enhancing catecholamine (dopamine, norepinephrine) signalling and inhibiting catecholamine catabolising enzyme, thereby increasing catecholamine concentrations. Through a variety of mechanisms, 2 MA use has been associated with damage to organ systems including neurotoxicity, myocardial infarction, cardiomyopathy, pulmonary haemorrhage, pulmonary oedema, acute lung injury and pulmonary hypertension [2][3][4][5][6][7][8] Originally recognised as a public health issue in the 1960s, 9 MA abuse is a growing epidemic. In 2019, approximately 27 million people worldwide had used amphetamine-type stimulants, behind only cannabis (200 million) and opioids (62 million).…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine-associated pulmonary arterial hypertension: data from the national biological sample and data repository for pulmonary arterial hypertension (PAH Biobank)

Charoenpong,

Dhillon,

Murnane

et al. 2023

BMJ Open Resp Res

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ObjectiveThis study compares the clinical and haemodynamic severity of methamphetamine-associated pulmonary arterial hypertension (MA-PAH) with idiopathic pulmonary arterial hypertension (IPAH) and connective tissue-associated pulmonary arterial hypertension (CTD-PAH). It also examines sex differences in clinical and physiological parameters among those with MA-PAH.DesignThis is a cross-sectional study using clinically derived data from the National Biological Sample and Data Repository for Pulmonary Arterial Hypertension (PAH biobank), a US-based registry, to compare clinical and physiological characteristics between males and females with MA-PAH.PopulationThe analysis included 1830 patients enrolled in the PAH biobank, with a diagnosis of MA-PAH (n=42), IPAH (n=1073), or CTD-PAH (n=715).Main outcome measuresThe study assessed and compared the clinical and haemodynamic parameters of patients with MA-PAH, IPAH and CTD-PAH.ResultsAmong the patients analysed, 42 had MA-PAH, with 69.1% being female. There were no statistically significant differences in functional class among patients with MA-PAH, IPAH and CTD-PAH. The per cent predicted 6-min walk distance (6MWD) was comparable between the three groups. Patients with MA-PAH had similar mean pulmonary artery pressure and pulmonary vascular resistance to patients with IPAH but higher compared with patients with CTD-PAH. Male patients with MA-PAH exhibited a worse functional class and lower per cent predicted 6MWD, but no significant differences in haemodynamic findings were observed between the sexes.ConclusionThere were no differences in haemodynamic between MA-PAH and IPAH but we found that MA-PAH differed from CTD-PAH. The study did not find evidence of sex differences in MA-PAH. Further research is necessary to identify risk factors and underlying mechanisms of MA-PAH, particularly considering the increasing prevalence of methamphetamine use. Such investigations will contribute to the development of effective prevention and treatment strategies for this condition.

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Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model

Liu

Chen

et al. 2023

Chemico-Biological Interactions

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Mitochondrial dysfunction and autophagy activation are associated with cardiomyopathy developed by extended methamphetamine self-administration in rats

Cited by 11 publications

References 95 publications

Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study

Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study

Methamphetamine-associated pulmonary arterial hypertension: data from the national biological sample and data repository for pulmonary arterial hypertension (PAH Biobank)

Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model

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