Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies

Kubat, Gokhan Burcin; Bouhamida, Esmaa; Ulger, Oner; Türkel, İbrahim; Pedriali, Gaia; Ramaccini, Daniela; Ekinci, Özgür; Özerkliğ, Berkay; Atalay, Özbeyen; Patergnani, Simone; Şahin, Bayram; Morciano, Giampaolo; Tuncer, Meltem; Tremoli, Elena; Pinton, Paolo

doi:10.1016/j.mito.2023.07.003

Cited by 30 publications

(6 citation statements)

References 419 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mitochondrial dysfunction plays a determinant role in the pathogenesis of skeletal muscle atrophy, since these organelles account for ATP production and regulation of metabolism, redox homeostasis, and apoptosis [ 48 ]. To elucidate a possible mechanism underlying the beneficial effects of AA mixture supplementation on TA architecture and performance in our models of skeletal muscle atrophy, several parameters related to mitochondria homeostasis were measured.…”

Section: Discussionmentioning

confidence: 99%

An Amino Acid Mixture to Counteract Skeletal Muscle Atrophy: Impact on Mitochondrial Bioenergetics

Bellanti,

Lo Buglio,

Pannone

et al. 2024

IJMS

View full text Add to dashboard Cite

Skeletal muscle atrophy (SMA) is caused by a rise in muscle breakdown and a decline in protein synthesis, with a consequent loss of mass and function. This study characterized the effect of an amino acid mixture (AA) in models of SMA, focusing on mitochondria. C57/Bl6 mice underwent immobilization of one hindlimb (I) or cardiotoxin-induced muscle injury (C) and were compared with controls (CTRL). Mice were then administered AA in drinking water for 10 days and compared to a placebo group. With respect to CTRL, I and C reduced running time and distance, along with grip strength; however, the reduction was prevented by AA. Tibialis anterior (TA) muscles were used for histology and mitochondria isolation. I and C resulted in TA atrophy, characterized by a reduction in both wet weight and TA/body weight ratio and smaller myofibers than those of CTRL. Interestingly, these alterations were lightly observed in mice treated with AA. The mitochondrial yield from the TA of I and C mice was lower than that of CTRL but not in AA-treated mice. AA also preserved mitochondrial bioenergetics in TA muscle from I and C mice. To conclude, this study demonstrates that AA prevents loss of muscle mass and function in SMA by protecting mitochondria.

show abstract

Section: Discussionmentioning

confidence: 99%

An Amino Acid Mixture to Counteract Skeletal Muscle Atrophy: Impact on Mitochondrial Bioenergetics

Bellanti,

Lo Buglio,

Pannone

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Recent research underscores the pivotal role of muscle mitochondria in the progression of cancer-induced cachexia [ 126 – 128 ] highlighting that mitochondrial dysfunction is a key driver of skeletal muscle wasting. Alterations in various mitochondrial processes observed in animal models of cancer cachexia are acknowledged to exacerbate cachexia’s development [ 129 – 131 ].…”

Section: Mitochondria Transcription and Cancer-associate Cachexiamentioning

confidence: 99%

Mitochondria transcription and cancer

Lei,

Rui,

Xiaoshuang

et al. 2024

Cell Death Discov.

View full text Add to dashboard Cite

Mitochondria are major organelles involved in several processes related to energy supply, metabolism, and cell proliferation. The mitochondria function is transcriptionally regulated by mitochondria DNA (mtDNA), which encodes the key proteins in the electron transport chain that is indispensable for oxidative phosphorylation (OXPHOS). Mitochondrial transcriptional abnormalities are closely related to a variety of human diseases, such as cardiovascular diseases, and diabetes. The mitochondria transcription is regulated by the mtDNA, mitochondrial RNA polymerase (POLRMT), two transcription factors (TFAM and TF2BM), one transcription elongation (TEFM), and one known transcription termination factor (mTERFs). Dysregulation of these factors directly leads to altered expression of mtDNA in tumor cells, resulting in cellular metabolic reprogramming and mitochondrial dysfunction. This dysregulation plays a role in modulating tumor progression. Therefore, understanding the role of mitochondrial transcription in cancer can have implications for cancer diagnosis, prognosis, and treatment. Targeting mitochondrial transcription or related pathways may provide potential therapeutic strategies for cancer treatment. Additionally, assessing mitochondrial transcriptional profiles or biomarkers in cancer cells or patient samples may offer diagnostic or prognostic information.

show abstract

“…Mitochondria have many different roles in skeletal muscle, and reducing their functionality can seriously harm muscle health ( Kubat et al, 2023 ; Turkel et al, 2023 ). In an acute limb ischemia model, mitochondrial transplantation dramatically reduced infarct size and apoptosis in the skeletal muscles such as gastrocnemius, soleus.…”

Section: Artificial Mitochondrial Transplantation and Transfer: In Vi...mentioning

confidence: 99%

“…Mitochondria-targeted antioxidants (SS31, Vitamin E, etc. ), stem cell therapy, and exercise are all common in the treatment of mitochondrial dysfunction-related diseases ( Akın et al, 2021 ; Kubat et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial transplantation and transfer: The promising method for diseases

KUBAT

2023

Turkish Journal of Biology

View full text Add to dashboard Cite

Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.

show abstract

Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies

Cited by 30 publications

References 419 publications

An Amino Acid Mixture to Counteract Skeletal Muscle Atrophy: Impact on Mitochondrial Bioenergetics

An Amino Acid Mixture to Counteract Skeletal Muscle Atrophy: Impact on Mitochondrial Bioenergetics

Mitochondria transcription and cancer

Mitochondrial transplantation and transfer: The promising method for diseases

Contact Info

Product

Resources

About