2017
DOI: 10.1016/j.semcancer.2017.05.002
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Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR

Abstract: Mitochondria form a cellular network of organelles, or cellular compartments, that efficiently couple nutrients to energy production in the form of ATP. As cancer cells rely heavily on glycolysis, historically mitochondria and the cellular pathways in place to maintain mitochondrial activities were thought to be more relevant to diseases observed in non-dividing cells such as muscles and neurons. However, more recently it has become clear that cancers rely heavily on mitochondrial activities including lipid, n… Show more

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Cited by 94 publications
(71 citation statements)
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References 140 publications
(128 reference statements)
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“…This further urges clarity about the role of MFN2 in ER–mitochondria appositions in both normal and cancerous cells. Finally, it is still not clear whether ER–mitochondria contact sites modulate the mitochondrial UPR, an emerging process modulating mitochondrial proteostasis ( 175 ). All these are outstanding questions that await future studies.…”
Section: Discussionmentioning
confidence: 99%
“…This further urges clarity about the role of MFN2 in ER–mitochondria appositions in both normal and cancerous cells. Finally, it is still not clear whether ER–mitochondria contact sites modulate the mitochondrial UPR, an emerging process modulating mitochondrial proteostasis ( 175 ). All these are outstanding questions that await future studies.…”
Section: Discussionmentioning
confidence: 99%
“…The transcription factor ATF5 was recently identified as the mammalian ortholog of ATFS-1 ( 101 ). While a body of literature is already present on the function of ATF5 in cancer biology, notably in the regulation of survival and apoptosis ( 102 , 103 ), it will be interesting to explore the role of ATF5 in the context of UPR mt and cancer, particularly in EMT regulation and metastasis.…”
Section: Mitochondrial Retrograde Signaling and Emtmentioning
confidence: 99%
“…These chaperones and proteases include HSP60, mtHSP70, and LONP1. While this research provides a novel function for ATF5 in cellular stress responses, it imposes further curiosity whether the UPR mt processes mediated by ATF5 can contribute to cancer development in ATF5-dysregulated cancers [ 46 ]. With this in mind, ATF4 has also been shown to regulate mitochondrial stress responses [ 7 ] and ATF4 and ATF5 are paralogs of ATFS-1.…”
Section: Mitochondrial Uprmentioning
confidence: 99%