Mitochondrial dysfunction in cardiovascular disease: Towards exercise regulation of mitochondrial function

Abstract

The morbidity and mortality of cardiovascular diseases are exceedingly high worldwide. Pathological heart remodeling, which is developed as a result of mitochondrial dysfunction, could ultimately drive heart failure. More recent research target exercise modulation of mitochondrial dysfunction to improve heart failure. Therefore, finding practical treatment goals and exercise programs to improve cardiovascular disease is instrumental. Better treatment options are available with the recent development of exercise and drug therapy. This paper summarizes pathological states of abnormal mitochondrial function and intervention strategies for exercise therapy.

Cardiac damage following renal ischemia reperfusion injury increased with excessive consumption of high fat diet but enhanced the cardiac resistance to reperfusion stress in rat

“…This was mainly due to the significant elevation in the inflammation in the cardiac tissue and the associated mild decrease in mitochondrial function. Many studies demonstrated the direct relationship between inflammation and mitochondrial dysfunction in developing cardiovascular abnormalities [ [50] , [51] , [52] ]. There exist many reports that link inflammation between a high-fat diet and diseases [ 53 , 54 ].…”

Glucose-Lowering Effects of Imeglimin and Its Possible Beneficial Effects on Diabetic Complications

“…Patients with type 2 diabetes are likely to develop heart failure (HF). HF canbe induced by pathological heart remodeling due to mitochondrial dysfunction [19]. Vice versa, the improvement in mitochondrial dysfunction can improve HF.…”