Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome

Abstract

Co-enzyme Q10 (Co-Q10) is an essential component of the mitochondrial electron transport chain. Most cells are sensitive to co-enzyme Q10 (Co-Q10) deficiency. This deficiency has been implicated in several clinical disorders such as heart failure, hypertension, Parkinson’s disease and obesity. The lipid lowering drug statin inhibits conversion of HMG-CoA to mevalonate and lowers plasma Co-Q10 concentrations. However, supplementation with Co-Q10 improves the pathophysiological condition of statin therapy. Recent evidence suggests that Co-Q10 supplementation may be useful for the treatment of obesity, oxidative stress and the inflammatory process in metabolic syndrome. The anti-inflammatory response and lipid metabolizing effect of Co-Q10 is probably mediated by transcriptional regulation of inflammation and lipid metabolism. This paper reviews the evidence showing beneficial role of Co-Q10 supplementation and its potential mechanism of action on contributing factors of metabolic and cardiovascular complications.

Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration

“…For instance, vitamin Co-Q10 supplementation is used during the treatment of obesity, oxidative stress (T2DM) and the inflammatory process in MetS. Co-Q10 served as an antioxidant by acting as a cofactor and activator of mitochondrial uncoupling proteins, responsible for the reduction in ROS production, endothelial dysfunction and hypertension [105,106]. Similarly, numerous other vitamins with antioxidant properties have also been developed to treat MetS induced by oxidative stress and mitochondrial dysfunctions.…”

Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

“…Coenzyme Q10 (CoQ10) or ubiquinone, a lipid-soluble [13] and vitamin-like compound [14], acts as a crucial cofactor in the mitochondrial respiratory chain as well as a natural scavenger of free radicals [15]. It is synthesized by cells of the body and also found in abundance in the human diet [16].…”

Effects of coenzyme Q10 supplementation on the anthropometric variables, lipid profiles and liver enzymes in patients with non-alcoholic fatty liver disease

“…The primary function of CoQ10 in cells is in generating energy; being at the core of cellular energy processes CoQ10 has potential for reduce weight by improving (Alam and Rahman, 2014) ; Inhibition of CoQ10 synthesis strongly triggered adipocyte differentiation while increment of CoQ10 acts in inverse direction (Bour et al, 2011). CoQ10 treatment increases fat oxidation and energy consumption in adipose tissue.…”