Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

Lee, Yulim; Ju, Xianshu; Cui, Jianchen; Zhang, Tao; Hong, Boohwi; Kim, Yoon Hee; Ko, Youngkwon; Park, Jiho; Choi, Chul Hee; Heo, Jun Young; Chung, Woosuk

doi:10.1016/j.heliyon.2024.e28974

Cited by 3 publications

(1 citation statement)

References 91 publications

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“…We have previously utilized this model and described similar defects in recognition memory. 13 In comparison to other studies, a onetime 0.33 mg/kg administration did not detect spatial memory impairment in young mice, 46 and 5 days of 0.25 mg/kg treatment resulted in reduced NOR performance, 15 reporting on no other behavioral changes (no others measured). Administration of 0.25–0.75 mg/kg for 7 sequential days appears to consistently induce cognitive decline across a broad range of cognitive domains, 47–50 with reduced spatial and recognition memory reported (Morris water maze, y maze NOR) however OF performance was only quantified (and found to be influenced by LPS) by Oz et al 50 Similar results were also reported in a study in which the seven injections were administered on alternative days (Water maze and Y maze), 51 again OF was not reported.…”

Section: Discussioncontrasting

confidence: 72%

A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation

Pontifex,

Connell,

Le Gall

et al. 2024

Gut Microbes

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Section: Discussioncontrasting

confidence: 72%

A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation

Pontifex,

Connell,

Le Gall

et al. 2024

Gut Microbes

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ATF5-Dependent GDF15 Expression Mediates Anesthesia-Induced Neuroprotection Against Stroke

Ju,

Zhang,

Cui

et al. 2024

Preprint

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The incidence of perioperative stroke, a rare but severe complication, is increasing in aging populations. Although anesthetics such as sevoflurane may provide protective preconditioning against ischemic injury, clinical outcomes have been inconsistent. In this study, we demonstrated that sevoflurane-induced neuroprotection is associated with the upregulation of genes involved in the mitochondrial unfolded protein response (UPRmt) and mitochondrial bioenergetic metabolism. Our findings emphasize the critical role of ATF5, a key transcription factor, in mediating these protective effects. Specifically, we observed that sevoflurane preconditioning significantly upregulates ATF5 and its downstream target GDF15 – a regulator of mitochondrial function – in the cerebral cortex. Notably, we found that this mechanistic pathway was not activated in the brain of aged mice, suggesting that age-specific strategies may be necessary for reducing the risk of perioperative stroke. Considering the steadily increasing age of patients, therapeutic approaches that enhance mitochondrial function in the aged brain may provide additional protection against perioperative stroke.

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Histopathological Analysis of Lipopolysaccharide-Induced Liver Inflammation and Thrombus Formation in Mice: The Protective Effects of Aspirin

Saitoh,

Sakaguchi,

Miruno

et al. 2024

CIMB

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Hepatitis, a significant medical concern owing to its potential to cause acute and chronic liver disease, necessitates early intervention. In this study, we aimed to elucidate the histopathological features of lipopolysaccharide-induced hepatitis in mice, focusing on tissue alterations. The results demonstrated that hepatocytes exhibited decreased eosin staining, indicating cellular shrinkage, whereas sinusoids were swollen with blood cells. Detailed electron microscope analysis identified these blood cells as leukocytes and erythrocytes, which confirmed a thrombus formation within the liver. Pre-treatment with aspirin significantly attenuated these pathological changes, including reductions in inflammatory markers such as C-reactive protein, interleukin-1β, and tumor necrosis factor-alpha. These findings highlight aspirin’s anti-inflammatory and antiplatelet effects in mitigating liver inflammation and thrombus formation. In this study, we highlighted the potential of aspirin as a therapeutic agent for liver inflammation, in addition to providing insights into hepatocyte alterations and sinusoidal blood cell aggregation in liver inflammation. Aspirin, through the protection of endothelial cells and reduction of cytokine levels, may have broader applications in managing liver disease and other systemic inflammatory conditions. This emphasizes its value in prevention and therapy.

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Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

Cited by 3 publications

References 91 publications

A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation

A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation

ATF5-Dependent GDF15 Expression Mediates Anesthesia-Induced Neuroprotection Against Stroke

Histopathological Analysis of Lipopolysaccharide-Induced Liver Inflammation and Thrombus Formation in Mice: The Protective Effects of Aspirin

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