2014
DOI: 10.1007/s11010-014-2114-3
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Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia

Abstract: Elevated levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), is an independent risk factor of various diseases. Clinical studies report that people born with severe HHcy develop skeletal malformations with weaker bone. Studies also report that altered mitochondrial dynamics and altered epigenetics contribute to weaker bones and bone diseases. Although Hcy-induced mitochondrial dysfunction has been shown to affect bone metabolism, the role of mitochondrial epigenetics (mito-epigenetics) has not … Show more

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Cited by 23 publications
(14 citation statements)
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“…Additionally neural tube defects, congenital heart defects, and nonsyndromic oral cleft, which appear to be related to hyperhomocysteinemia (15,70,95), might be characterized by epigenetic abnormalities. Recently a potential link between homocysteine, mitochondrial epigenetics, and bone remodeling was identified, suggesting the homocysteine synthesis could be another key regulatory point of epigenetic mechanisms (47,94). However, the mechanisms of this relationship needs to be fully understood.…”
Section: Mitochondrial Dna Methylation: New Frontier Of Cross Talkmentioning
confidence: 99%
“…Additionally neural tube defects, congenital heart defects, and nonsyndromic oral cleft, which appear to be related to hyperhomocysteinemia (15,70,95), might be characterized by epigenetic abnormalities. Recently a potential link between homocysteine, mitochondrial epigenetics, and bone remodeling was identified, suggesting the homocysteine synthesis could be another key regulatory point of epigenetic mechanisms (47,94). However, the mechanisms of this relationship needs to be fully understood.…”
Section: Mitochondrial Dna Methylation: New Frontier Of Cross Talkmentioning
confidence: 99%
“…MR improves health by improving insulin sensitivity and glucose metabolism with reduced accumulation of hepatic triglycerides [Perrone et al, ; Plaisance et al, ], oxidative stress [Caro et al, ; Johnson and Johnson, ], and adiposity in many of the depots in the body [Lees et al, ]. Although these are wonderful benefits, it is not clear whether all tissues will benefit from MR. Growth restriction was seen in young male rodents on MR [Ables et al, ; Huang et al, ] and mice on MR become hyperhomocysteinemic, which could lead to reduced blood flow in bone and retard growth [Tyagi et al, ; Vijayan et al, ; Kalani et al, ]. In rats and mice, MR was reported to reduce bone mass density and mineral content when compared to bones of CF mice [Ables et al, ; Huang et al, ].…”
Section: Discussionmentioning
confidence: 99%
“…The underlying mechanisms between plasma Hcy levels and fractures are uncertain. The potential mechanisms include the regulative role of Hcy on bone tissue quality through altering the properties of collagen crosslink [ 25 ], affecting bone resorption by stimulating osteoclast formation and activity [ 26 ], and inducing mitochondrial dysfunction [ 27 ].…”
Section: Discussionmentioning
confidence: 99%