Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells

Bilska, Bernadetta; Schedel, Fiona; Piotrowska, Anna; Stefan, Joanna; Żmijewski, Michał A.; Pyza, Elżbieta; Reíter, Russel J.; Steinbrink, Kerstin; Slominski, Andrzej; Tulić, Meri K.; Kleszczyński, Konrad

doi:10.1111/jpi.12728

Cited by 24 publications

(28 citation statements)

References 95 publications

(256 reference statements)

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“…Environmental air pollutants promote mitochondrial dysfunction and oxidative damage due to excessive ROS generation, potentially resulting in prematurely aged skin and skin cancer [107,108]. Melatonin can restore the mitochondrial function and maintain the mitochondrial homeostasis [275]. It can reach the mitochondria by crossing the cell membranes, and it can also be synthesized in the mitochondrion.…”

Section: Role Of Melatonin and Its Metabolites In The Attenuation Of ...mentioning

confidence: 99%

Protective Role of Melatonin and Its Metabolites in Skin Aging

Bocheva

Slominski

Janjetovic

et al. 2022

IJMS

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The skin, being the largest organ in the human body, is exposed to the environment and suffers from both intrinsic and extrinsic aging factors. The skin aging process is characterized by several clinical features such as wrinkling, loss of elasticity, and rough-textured appearance. This complex process is accompanied with phenotypic and functional changes in cutaneous and immune cells, as well as structural and functional disturbances in extracellular matrix components such as collagens and elastin. Because skin health is considered one of the principal factors representing overall “well-being” and the perception of “health” in humans, several anti-aging strategies have recently been developed. Thus, while the fundamental mechanisms regarding skin aging are known, new substances should be considered for introduction into dermatological treatments. Herein, we describe melatonin and its metabolites as potential “aging neutralizers”. Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. It regulates circadian rhythmicity and also exerts anti-oxidative, anti-inflammatory, immunomodulatory, and anti-tumor capacities. The intention of this review is to summarize changes within skin aging, research advances on the molecular mechanisms leading to these changes, and the impact of the melatoninergic anti-oxidative system controlled by melatonin and its metabolites, targeting the prevention or reversal of skin aging.

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Section: Role Of Melatonin and Its Metabolites In The Attenuation Of ...mentioning

confidence: 99%

Protective Role of Melatonin and Its Metabolites in Skin Aging

Bocheva

Slominski

Janjetovic

et al. 2022

IJMS

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“…The highest melatonin concentrations are found in mitochondria [ 23 , 24 ], raising the possibility of functional significance for the involvement in mitochondrial activities [ 25 , 26 ]. For instance, most apoptotic signals originate in the mitochondria, and melatonin has well-known anti-apoptotic [ 27 , 28 , 29 ], anti-inflammatory [ 30 ], pro-differentiation [ 31 , 32 , 33 ], and oncostatic effects [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Melatonin acts through two major pathways: A receptor-mediated pathway (membrane, cytosolic, and nuclear receptors) and a receptor-independent pathway [ 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing

Kaczmarek-Szczepańska

Ostrowska

Kozłowska

et al. 2021

IJMS

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The development of scaffolds mimicking the extracellular matrix containing bioactive substances has great potential in tissue engineering and wound healing applications. This study investigates melatonin—a methoxyindole present in almost all biological systems. Melatonin is a bioregulator in terms of its potential clinical importance for future therapies of cutaneous diseases. Mammalian skin is not only a prominent melatonin target, but also produces and rapidly metabolizes the multifunctional methoxyindole to biologically active metabolites. In our methodology, chitosan/collagen (CTS/Coll)-contained biomaterials are blended with melatonin at different doses to fabricate biomimetic hybrid scaffolds. We use rat tail tendon- and Salmo salar fish skin-derived collagens to assess biophysical and cellular properties by (i) Fourier transform infrared spectroscopy—attenuated total reflectance (FTIR–ATR), (ii) thermogravimetric analysis (TG), (iii) scanning electron microscope (SEM), and (iv) proliferation ratio of cutaneous cells in vitro. Our results indicate that melatonin itself does not negatively affect biophysical properties of melatonin-immobilized hybrid scaffolds, but it induces a pronounced elevation of cell viability within human epidermal keratinocytes (NHEK), dermal fibroblasts (NHDF), and reference melanoma cells. These results demonstrate that this indoleamine accelerates re-epithelialization. This delivery is a promising technique for additional explorations in future dermatotherapy and protective skin medicine.

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“…Melatonin is a product secreted by the pineal gland that has various functions, including antioxidant properties. Melatonin either collects free radicals directly or indirectly by collecting the power of antioxidant enzymes in the body to collect free radicals (17). Melatonin effectively protects the DNA of the nucleus and membrane lipids, and cytoplasmic proteins and improves the antioxidant capacity of the whole organism.…”

Section: Resultsmentioning

confidence: 99%

“…Norepinephrine is received in pinealocytes by alpha and beta-adrenergic receptors, increasing the production of cyclic AMP and converting serotonin to melatonin in the melatonin synthesis pathway. Melatonin enters the blood and ventricles of the brain and enters the cerebrospinal fluid from the ventricles (17).…”

Section: Introductionmentioning

confidence: 99%

“…Melatonin has several functions, including the treatment of insomnia and delaying the aging process. Melatonin affects many physiological activities such as neuroendocrine function and puberty (17,18). In addition, melatonin has potent antioxidant activity that protects cells, tissues, and organs from damage by reactive oxygen species (ROS) (19).…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of melatonin as an antioxidant in the intestine of rats with superior mesenteric arterial occlusion

Yuan

Zhang

2022

Cell Mol Biol (Noisy-le-grand)

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The superior mesenteric artery is a branch of the aortic artery that supplies blood to the small and some parts of the large intestine. Any obstruction in blood flow and reperfusion causes tissue damage in the intestine. This study aimed to determine the rate of fat peroxidation and tissue protein as an indicator of tissue degradation after ischemia and reperfusion following induction of superior mesenteric artery occlusion in the intestine and to evaluate the protective effect of melatonin as a free radical scavenger and antioxidants in rats. In this study, 36 male Wistar-Albino rats weighing between 80-120 g were equally divided into six groups and received different melatonin doses (10, 20, and 30 mg/kg) intramuscularly. In this regard, Group 1 was the control group, Group 2 was the Sham group (underwent surgery to dissect the upper mesenteric artery and injected the same volume of solvent), Group 3 was Ischemia-reperfusion (IR), Group 4 was IR with melatonin at a dose of 10 mg/kg, Group 5 was IR with melatonin at a dose of 20 mg/kg, and Group 6 was IR with melatonin at a dose of 30 mg/kg. The results showed that the level of tissue malondialdehyde (MDA) was significantly lower in groups 4, 5, and 6 than in group 3 (P <0.05). Tissue protein levels were significantly higher in group 4 than in group 3 (P <0.001). Tissue protein levels in groups 5 and 6 did not significantly differ from group 3 (P = 0.191). Overall, this study showed that melatonin at a dose of 10 mg/kg has an antioxidant effect preventing induced damage due to superior mesenteric artery occlusion.

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Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 24 publications

References 95 publications

Protective Role of Melatonin and Its Metabolites in Skin Aging

Protective Role of Melatonin and Its Metabolites in Skin Aging

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing

Protective effect of melatonin as an antioxidant in the intestine of rats with superior mesenteric arterial occlusion

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