Mitochondrial gene expression in the liver and muscle of high and low feed efficiency Japanese quail layers subjected to different environmental temperatures

Voltolini, Débora Marques; Vesco, Ana Paula Del; Gasparino, Eliane; Guimarães, Simone Eliza Facioni; Neto, Adhemar Rodrigues Oliveira; Batista, Eliany; Ton, Ana Paula Silva

doi:10.4238/2014.july.4.8

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Other work has documented gluconeogenesis as a significantly upregulated pathway in laboratory rats given dietary toxins and housed at higher temperature (Settivari et al., , ). Likewise, the expression of a mitochondrial energy synthesis gene was significantly upregulated in liver of Japanese quail (adenine nucleotide translocator (ANT), Voltolini et al., ). Conversely, cooler temperatures could represent a “release state” in the liver whereby more gene expression is permitted by lower temperatures.…”

Section: Discussionmentioning

confidence: 99%

Ambient temperature‐mediated changes in hepatic gene expression of a mammalian herbivore (Neotoma lepida)

2017

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Herbivores regularly ingest natural toxins produced by plants as a defence against herbivory. Recent work suggests that compound toxicity is exacerbated at higher ambient temperatures. This phenomenon, known as temperature-dependent toxicity (TDT), is the likely result of decreased liver function at warmer temperatures; however, the underlying cause of TDT remains speculative. In the present study, we compared the effects of temperature and dietary plant toxins on differential gene expression in the liver of an herbivorous rodent (Neotoma lepida), using species-specific microarrays. Expression profiles revealed a greater number of differentially expressed genes at an ambient temperature below the thermal neutral zone for N. lepida (22°C) compared to one within (27°C). Genes and pathways upregulated at 22°C were related to growth and biosynthesis, whereas those upregulated at 27°C were associated with gluconeogenesis, apoptosis and protein misfolding, suggestive of a stressed state for the liver. Additionally, few genes associated with xenobiotic metabolism were induced when woodrats ingested plant toxins compared to nontoxic diets, regardless of temperature. Taken together, the results highlight the important role of ambient temperature on gene expression profiles in the desert woodrat. Temperatures just below the thermal neutral zone might be a favourable state for liver metabolism. Furthermore, the reduction in the number of genes expressed at a temperature within the thermal neutral zone indicates that liver function may be reduced at temperatures that are not typically considered as thermally stressful. Understanding how herbivorous mammals will respond to ambient temperature is imperative to accurately predict the impacts of climate change.

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Section: Discussionmentioning

confidence: 99%

Ambient temperature‐mediated changes in hepatic gene expression of a mammalian herbivore (Neotoma lepida)

2017

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The role of heat shock protein 70 in oxidant stress and inflammatory injury in quail spleen induced by cold stress

Jia-yi

Liu

Zhao

et al. 2018

Environ Sci Pollut Res

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The aim of this study was to investigate the role of heat shock protein 70 (Hsp70) in oxidative stress and inflammatory damage in the spleen of quails which were induced by cold stress. One hundred ninety-two 15-day-old male quails were randomly divided into 12 groups and kept at 12 ± 1 °C to examine acute and chronic cold stress. We first detected the changes in activities of antioxidant enzymes in the spleen tissue under acute and chronic cold stress. The activities of glutathione peroxidase (GSH-Px) fluctuated in acute cold stress groups, while they were significantly decreased (p < 0.05) after chronic cold stress. The activities of superoxide dismutase (SOD), inducible nitric oxide synthase (iNOS), and nitric oxide (NO) content were decreased significantly (p < 0.05) in both of the acute and chronic cold stress groups. Malondialdehyde (MDA) content was significantly increased (p < 0.05) under cold stress except the 0.5 h group of acute cold stress. Besides, histopathological analysis showed that quail's spleen tissue was inflammatory injured seriously in both the acute and chronic cold stress groups. Additionally, the inflammatory factors (cyclooxygenase-2 (COX-2), prostaglandin E synthase (PTGES), iNOS, nuclear factor-kappa B (NF-κB), and tumor necrosis factor-a (TNF-α)) and Hsp70 mRNA levels were increased in both of the acute and chronic cold stress groups compared with the control groups. These results suggest that oxidative stress and inflammatory injury could be induced by cold stress in spleen tissues of quails. Furthermore, the increased expression of Hsp70 may play a role in protecting the spleen against oxidative stress and inflammatory damage caused by cold stress.

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A systematic review on the trend of transcriptomic study in livestock: An effort to unwind the complexity of adaptation in a climate change environment

Astuti,

Sárkány,

Wanjala

et al. 2025

Heliyon

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Mitochondrial gene expression in the liver and muscle of high and low feed efficiency Japanese quail layers subjected to different environmental temperatures

Cited by 4 publications

References 31 publications

Ambient temperature‐mediated changes in hepatic gene expression of a mammalian herbivore (Neotoma lepida)

Ambient temperature‐mediated changes in hepatic gene expression of a mammalian herbivore (Neotoma lepida)

The role of heat shock protein 70 in oxidant stress and inflammatory injury in quail spleen induced by cold stress

A systematic review on the trend of transcriptomic study in livestock: An effort to unwind the complexity of adaptation in a climate change environment

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